Review on the Recent Progress in the Development of Fluorescent ProbesTargeting Enzymes.

Biomolecules are very important for biological processes in a living being, performing similar or multiple tasks in and out of cells, tissues and other organisms at a particular location. The abnormal activity of particular biomolecule usually caused serious diseases such as Alzheimer's disease, Parkinson's disease, cancers, diabetes, cardiovascular diseases, arthritis etc. Hence, nondestructive and real-time visualization for certain subcellular tissue is very important for understanding the biological issues, as well as the drug administration and drug metabolism. Fluorescent cellular probe-based target bimolecular detection in vitro and in vivo has become broad interest for human disease diagnostics and therapeutics. This review highlights the recent findings and designs of highly sensitive and selective fluorescent cellular probes targeting biomolecules for fluorescent analysis and imaging.