Maha Al-Ghafry1, Anshul Vagrecha1, Marium Malik1, Chana Levine1, Eliza Uster2, Banu Aygun1, Abena Appiah-Kubi1, Adrianna Vlachos1,3, Christine A Capone3,4,5, Sujatha Rajan6, Nancy Palumbo7, Nilanjana Misra5, Elizabeth C Mitchell5, Lawrence C Wolfe1, Jeffrey M Lipton1,3, Linda Shore-Lesserson8, Suchitra S Acharya1. 1. Division of Pediatric Hematology/Oncology and Cellular Therapy, Cohen Children's Medical Center, New Hyde Park, New York. 2. Division of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York. 3. Feinstein Institutes for Medical Research, Manhasset. 4. Division of Pediatric Critical Care Medicine, Cohen Children's Medical Center, New Hyde Park, New York. 5. Division of Pediatric Cardiology, Cohen Children's Medical Center, New Hyde Park, New York. 6. Division of Pediatric Infectious Disease, Cohen Children's Medical Center, New Hyde Park, New York. 7. Division of Pediatric Hospital Medicine, Cohen Children's Medical Center, New Hyde Park, New York. 8. Division of Anesthesiology, North Shore University Hospital, Manhasset.
Abstract
BACKGROUND: Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had high rates of thrombosis. A novel condition in children infected with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), has limited data on their prothrombotic state or need for thromboprophylaxis. OBJECTIVES: We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis. METHODS: This analysis included patients (< 21 years of age) with a diagnosis of MIS-C (n=40) and controls (presenting with suspicion of MIS-C but later ruled out; n=26). RESULTS: MIS-C patients had higher levels of inflammatory markers including D-dimer (p<0.0001), compared to controls, along with evidence of hypercoagulability on ROTEM with elevated FIBTEM MCF (p<0.05). For MIS-C patients with D-dimers >1000 ng/mL, there was a significant correlation of FIBTEM MCF (p<0.0001) with a mean value of 37.4 (standard deviation 5.1). D-dimer >2144 ng/mL was predictive of intensive care unit admission (area under the curve (AUC) 0.80, 95% CI: 0.60-0.99; p<0.01; sensitivity: 82%, specificity: 75%), and elevated FIBTEM MCF (AUC 1 for >2500 ng/mL). MIS-C patients (50%) received enoxaparin thromboprophylaxis (in addition to aspirin) with significant improvement in their inflammatory and ROTEM parameters upon outpatient follow up; none developed symptomatic thrombosis. CONCLUSIONS: Despite an observed prothrombotic state, none of the MIS-C patients (on aspirin alone or in combination with enoxaparin) developed symptomatic thrombosis. ROTEM, in addition to coagulation profiles, may be helpful to tailor thromboprophylaxis in critically ill MIS-C patients. This article is protected by copyright. All rights reserved.
BACKGROUND: Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had high rates of thrombosis. A novel condition in childreninfected with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), has limited data on their prothrombotic state or need for thromboprophylaxis. OBJECTIVES: We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis. METHODS: This analysis included patients (< 21 years of age) with a diagnosis of MIS-C (n=40) and controls (presenting with suspicion of MIS-C but later ruled out; n=26). RESULTS:MIS-C patients had higher levels of inflammatory markers including D-dimer (p<0.0001), compared to controls, along with evidence of hypercoagulability on ROTEM with elevated FIBTEM MCF (p<0.05). For MIS-C patients with D-dimers >1000 ng/mL, there was a significant correlation of FIBTEM MCF (p<0.0001) with a mean value of 37.4 (standard deviation 5.1). D-dimer >2144 ng/mL was predictive of intensive care unit admission (area under the curve (AUC) 0.80, 95% CI: 0.60-0.99; p<0.01; sensitivity: 82%, specificity: 75%), and elevated FIBTEM MCF (AUC 1 for >2500 ng/mL). MIS-C patients (50%) received enoxaparin thromboprophylaxis (in addition to aspirin) with significant improvement in their inflammatory and ROTEM parameters upon outpatient follow up; none developed symptomatic thrombosis. CONCLUSIONS: Despite an observed prothrombotic state, none of the MIS-C patients (on aspirin alone or in combination with enoxaparin) developed symptomatic thrombosis. ROTEM, in addition to coagulation profiles, may be helpful to tailor thromboprophylaxis in critically ill MIS-Cpatients. This article is protected by copyright. All rights reserved.
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