Matthew P Cheng1, Alessandro Cau, Todd C Lee, Daniel Brodie, Arthur Slutsky, John Marshall, Srin Murthy, Terry Lee, Joel Singer, Koray K Demir, John Boyd, Hyejee Ohm, David Maslove, Alberto Goffi, Isaac I Bogoch, David D Sweet, Keith R Walley, James A Russell. 1. Department of Medicine, McGill University, Montreal, PQ, Canada. Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY. Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada. Centre for Health Evaluation and Outcomes Science (CHEOS), University of British Columbia, Vancouver, BC, Canada. Department of Medicine, Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada. Department of Medicine and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. Divisions of Internal Medicine and Infectious Diseases, Department of Medicine, Toronto General Hospital, University Health Network, Toronto, ON, Canada. Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
Abstract
OBJECTIVES: Severe acute respiratory syndrome-related coronavirus-2 binds and inhibits angiotensin-converting enzyme-2. The frequency of acute cardiac injury in patients with coronavirus disease 2019 is unknown. The objective was to compare the rates of cardiac injury by angiotensin-converting enzyme-2-binding viruses from viruses that do not bind to angiotensin-converting enzyme-2. DATA SOURCES: We performed a systematic review of coronavirus disease 2019 literature on PubMed and EMBASE. STUDY SELECTION: We included studies with ten or more hospitalized adults with confirmed coronavirus disease 2019 or other viral pathogens that described the occurrence of acute cardiac injury. This was defined by the original publication authors or by: 1) myocardial ischemia, 2) new cardiac arrhythmia on echocardiogram, or 3) new or worsening heart failure on echocardiogram. DATA EXTRACTION: We compared the rates of cardiac injury among patients with respiratory infections with viruses that down-regulate angiotensin-converting enzyme-2, including H1N1, H5N1, H7N9, and severe acute respiratory syndrome-related coronavirus-1, to those with respiratory infections from other influenza viruses that do not bind angiotensin-converting enzyme-2, including Influenza H3N2 and influenza B. DATA SYNTHESIS: Of 57 studies including 34,072 patients, acute cardiac injury occurred in 50% (95% CI, 44-57%) of critically ill patients with coronavirus disease 2019. The overall risk of acute cardiac injury was 21% (95% CI, 18-26%) among hospitalized patients with coronavirus disease 2019. In comparison, 37% (95% CI, 26-49%) of critically ill patients with other respiratory viruses that bind angiotensin-converting enzyme-2 (p = 0.061) and 12% (95% CI, 7-22%) of critically ill patients with other respiratory viruses that do not bind angiotensin-converting enzyme-2 (p < 0.001) experienced a cardiac injury. CONCLUSIONS: Acute cardiac injury may be associated with whether the virus binds angiotensin-converting enzyme-2. Acute cardiac injury occurs in half of critically ill coronavirus disease 2019 patients, but only 12% of patients infected by viruses that do not bind to angiotensin-converting enzyme-2.
OBJECTIVES:Severe acute respiratory syndrome-related coronavirus-2 binds and inhibits angiotensin-converting enzyme-2. The frequency of acute cardiac injury in patients with coronavirus disease 2019 is unknown. The objective was to compare the rates of cardiac injury by angiotensin-converting enzyme-2-binding viruses from viruses that do not bind to angiotensin-converting enzyme-2. DATA SOURCES: We performed a systematic review of coronavirus disease 2019 literature on PubMed and EMBASE. STUDY SELECTION: We included studies with ten or more hospitalized adults with confirmed coronavirus disease 2019 or other viral pathogens that described the occurrence of acute cardiac injury. This was defined by the original publication authors or by: 1) myocardial ischemia, 2) new cardiac arrhythmia on echocardiogram, or 3) new or worsening heart failure on echocardiogram. DATA EXTRACTION: We compared the rates of cardiac injury among patients with respiratory infections with viruses that down-regulate angiotensin-converting enzyme-2, including H1N1, H5N1, H7N9, and severe acute respiratory syndrome-related coronavirus-1, to those with respiratory infections from other influenza viruses that do not bind angiotensin-converting enzyme-2, including InfluenzaH3N2 and influenza B. DATA SYNTHESIS: Of 57 studies including 34,072 patients, acute cardiac injury occurred in 50% (95% CI, 44-57%) of critically illpatients with coronavirus disease 2019. The overall risk of acute cardiac injury was 21% (95% CI, 18-26%) among hospitalized patients with coronavirus disease 2019. In comparison, 37% (95% CI, 26-49%) of critically illpatients with other respiratory viruses that bind angiotensin-converting enzyme-2 (p = 0.061) and 12% (95% CI, 7-22%) of critically illpatients with other respiratory viruses that do not bind angiotensin-converting enzyme-2 (p < 0.001) experienced a cardiac injury. CONCLUSIONS: Acute cardiac injury may be associated with whether the virus binds angiotensin-converting enzyme-2. Acute cardiac injury occurs in half of critically ill coronavirus disease 2019 patients, but only 12% of patientsinfected by viruses that do not bind to angiotensin-converting enzyme-2.
Authors: Halil İbrahim Biter; Muhsin Kalyoncuoğlu; Aydın Rodi Tosu; Sinem Çakal; Ziya Apaydın; Ayça Gümüşdağ; Tufan Çınar; Ferhat Eyüpkoca; Erdal Belen; Mehmet Mustafa Can Journal: Rev Assoc Med Bras (1992) Date: 2022-09 Impact factor: 1.712
Authors: Arutha Kulasinghe; Ning Liu; Chin Wee Tan; James Monkman; Jane E Sinclair; Dharmesh D Bhuva; David Godbolt; Liuliu Pan; Andy Nam; Habib Sadeghirad; Kei Sato; Gianluigi Li Bassi; Ken O'Byrne; Camila Hartmann; Anna Flavia Ribeiro Dos Santos Miggiolaro; Gustavo Lenci Marques; Lidia Zytynski Moura; Derek Richard; Mark Adams; Lucia de Noronha; Cristina Pellegrino Baena; Jacky Y Suen; Rakesh Arora; Gabrielle T Belz; Kirsty R Short; Melissa J Davis; Fernando Souza-Fonseca Guimaraes; John F Fraser Journal: Immunology Date: 2022-09-15 Impact factor: 7.215