Literature DB >> 33869095

Severe Complication of Thiopurine Treatment in a Young Woman with Crohn's Disease.

Mpj Voet1, Tga Calon1, Mmc Hendriks1, R M Schreuder2.   

Abstract

CASE DESCRIPTION: A 28-year old woman receiving thiopurine treatment for Crohn's disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis). Secondary to this systemic infection, she developed splenomegaly, pancytopenia and lymphadenopathy. Anti-viral treatment resulted in complete resolution of clinical, biochemical and radiological abnormalities within 6 weeks.
CONCLUSION: Early recognition is crucial since CMV infection in a patient receiving thiopurine treatment may result in serious complications. LEARNING POINTS: Cytomegalovirus (CMV) infection in patients receiving thiopurine treatment may result in serious complications.This case report describes extensive primo CMV infection causing colitis, hepatitis, pneumonitis and retinitis in a patient receiving thiopurine treatment.Early recognition and treatment of the infection is crucial. © EFIM 2021.

Entities:  

Keywords:  Cytomegalovirus; colitis; hepatitis; pneumonitis; thiopurine

Year:  2021        PMID： 33869095      PMCID： PMC8046284          DOI： 10.12890/2021_002350

Source DB:  PubMed          Journal:  Eur J Case Rep Intern Med        ISSN： 2284-2594


  13 in total

1.  Cytomegalovirus disease, haemophagocytic syndrome, immunosuppression in patients with IBD: 'a cocktail best avoided, not stirred'.

Authors:  Daniel R van Langenberg; Graham Morrison; Anna Foley; Raymond J Buttigieg; Peter R Gibson
Journal:  J Crohns Colitis       Date:  2011-05-24       Impact factor: 9.071

2.  A case report of CMV lymphadenitis in an adult kidney transplant recipient.

Authors:  E L Lum; J M Schaenman; M DeNicola; U G Reddy; J I Shen; S T Pullarkat
Journal:  Transplant Proc       Date:  2015 Jan-Feb       Impact factor: 1.066

3.  Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.

Authors:  Vincent F Biank; Mehul K Sheth; Julie Talano; David Margolis; Pippa Simpson; Subra Kugathasan; Michael Stephens
Journal:  J Pediatr       Date:  2011-06-30       Impact factor: 4.406

Review 4.  Cytomegalovirus pneumonia in patients with inflammatory bowel disease: a systematic review.

Authors:  Antonio Cascio; Chiara Iaria; Paolo Ruggeri; Walter Fries
Journal:  Int J Infect Dis       Date:  2012-05-22       Impact factor: 3.623

5.  Corticosteroids and Thiopurines, But Not Tumor Necrosis Factor Antagonists, are Associated With Cytomegalovirus Reactivation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Authors:  Tushar Shukla; Siddharth Singh; Parul Tandon; Jeffrey D McCurdy
Journal:  J Clin Gastroenterol       Date:  2017 May/Jun       Impact factor: 3.062

6.  Outcome of cytomegalovirus infections in patients with inflammatory bowel disease.

Authors:  K A Papadakis; J K Tung; S W Binder; L Y Kam; M T Abreu; S R Targan; E A Vasiliauskas
Journal:  Am J Gastroenterol       Date:  2001-07       Impact factor: 10.864

7.  3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management.

Authors:  Fernando Gomollón; Axel Dignass; Vito Annese; Herbert Tilg; Gert Van Assche; James O Lindsay; Laurent Peyrin-Biroulet; Garret J Cullen; Marco Daperno; Torsten Kucharzik; Florian Rieder; Sven Almer; Alessandro Armuzzi; Marcus Harbord; Jost Langhorst; Miquel Sans; Yehuda Chowers; Gionata Fiorino; Pascal Juillerat; Gerassimos J Mantzaris; Fernando Rizzello; Stephan Vavricka; Paolo Gionchetti
Journal:  J Crohns Colitis       Date:  2016-09-22       Impact factor: 9.071

8.  Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.

Authors:  Laurent Beaugerie; Nicole Brousse; Anne Marie Bouvier; Jean Frédéric Colombel; Marc Lémann; Jacques Cosnes; Xavier Hébuterne; Antoine Cortot; Yoram Bouhnik; Jean Pierre Gendre; Tabassome Simon; Marc Maynadié; Olivier Hermine; Jean Faivre; Fabrice Carrat
Journal:  Lancet       Date:  2009-11-07       Impact factor: 79.321

9.  European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease.

Authors:  J F Rahier; S Ben-Horin; Y Chowers; C Conlon; P De Munter; G D'Haens; E Domènech; R Eliakim; A Eser; J Frater; M Gassull; M Giladi; A Kaser; M Lémann; T Moreels; A Moschen; R Pollok; W Reinisch; M Schunter; E F Stange; H Tilg; G Van Assche; N Viget; B Vucelic; A Walsh; G Weiss; Y Yazdanpanah; Y Zabana; S P L Travis; J F Colombel
Journal:  J Crohns Colitis       Date:  2009-04-26       Impact factor: 9.071

Review 10.  Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review.

Authors:  Petros I Rafailidis; Eleni G Mourtzoukou; Ioannis C Varbobitis; Matthew E Falagas
Journal:  Virol J       Date:  2008-03-27       Impact factor: 4.099
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  1 in total

Review 1.  Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?

Authors:  Carla J Gargallo-Puyuelo; Viviana Laredo; Fernando Gomollón
Journal:  Front Med (Lausanne)       Date:  2021-07-16
  1 in total

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