Charlotte King1, Eleanor Dixon2, Daniel B Hawcutt3,4. 1. Liverpool University Hospital NHS Foundation Trust, Liverpool, UK. 2. Department of Pharmacology and Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. 3. NIHR Alder Hey Clinical Research Facility, Alder Hey Children's Hospital, Liverpool, UK. 4. Department of Paediatric Clinical Pharmacology, University of Liverpool, Liverpool, UK.