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Literature DB >> 33865677

Structural basis of bacterial flagellar motor rotation and switching.

Yunjie Chang¹, Brittany L Carroll¹, Jun Liu².

Abstract

The bacterial flagellar motor, a remarkable rotary machine, can rapidly switch between counterclockwise (CCW) and clockwise (CW) rotational directions to control the migration behavior of the bacterial cell. The flagellar motor consists of a bidirectional spinning rotor surrounded by torque-generating stator units. Recent high-resolution in vitro and in situ structural studies have revealed stunning details of the individual components of the flagellar motor and their interactions in both the CCW and CW senses. In this review, we discuss these structures and their implications for understanding the molecular mechanisms underlying flagellar rotation and switching.

Entities: Chemical

Keywords: bacterial motility; rotary machine; rotational switching; rotor–stator interactions; torque generation

Mesh：

Substances：

Year: 2021 PMID： 33865677 PMCID： PMC8510993 DOI： 10.1016/j.tim.2021.03.009

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

70 in total

Review 1. The flagellum in bacterial pathogens: For motility and a whole lot more.

Authors: Bonnie Chaban; H Velocity Hughes; Morgan Beeby
Journal: Semin Cell Dev Biol Date: 2015-11-03 Impact factor: 7.727

Review 2. Coordinating assembly of a bacterial macromolecular machine.

Authors: Fabienne F V Chevance; Kelly T Hughes
Journal: Nat Rev Microbiol Date: 2008-06 Impact factor: 60.633

3. Evaluation of the Duty Ratio of the Bacterial Flagellar Motor by Dynamic Load Control.

Authors: Kento Sato; Shuichi Nakamura; Seishi Kudo; Shoichi Toyabe
Journal: Biophys J Date: 2019-04-11 Impact factor: 4.033

4. Mechanism for adaptive remodeling of the bacterial flagellar switch.

Authors: Pushkar P Lele; Richard W Branch; Vedhavalli S J Nathan; Howard C Berg
Journal: Proc Natl Acad Sci U S A Date: 2012-11-19 Impact factor: 11.205

5. Chemotaxis signaling protein CheY binds to the rotor protein FliN to control the direction of flagellar rotation in Escherichia coli.

Authors: Mayukh K Sarkar; Koushik Paul; David Blair
Journal: Proc Natl Acad Sci U S A Date: 2010-05-03 Impact factor: 11.205

6. The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.

Authors: Seiji Kojima; Masato Takao; Gaby Almira; Ikumi Kawahara; Mayuko Sakuma; Michio Homma; Chojiro Kojima; Katsumi Imada
Journal: Structure Date: 2018-03-22 Impact factor: 5.006

Structural basis of bacterial flagellar motor rotation and switching.

Review 1. The flagellum in bacterial pathogens: For motility and a whole lot more.

Review 2. Coordinating assembly of a bacterial macromolecular machine.

3. Evaluation of the Duty Ratio of the Bacterial Flagellar Motor by Dynamic Load Control.

4. Mechanism for adaptive remodeling of the bacterial flagellar switch.

5. Chemotaxis signaling protein CheY binds to the rotor protein FliN to control the direction of flagellar rotation in Escherichia coli.

6. The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.

7. Speed of the bacterial flagellar motor near zero load depends on the number of stator units.

8. The switching mechanism of the bacterial rotary motor combines tight regulation with inherent flexibility.

9. The role of the bacterial flagellum in adhesion and virulence.

10. Stoichiometry and turnover of the bacterial flagellar switch protein FliN.

Review 1. The Bacterial Flagellar Motor: Insights Into Torque Generation, Rotational Switching, and Mechanosensing.

2. FliL ring enhances the function of periplasmic flagella.

Review 3. A new class of biological ion-driven rotary molecular motors with 5:2 symmetry.