Bei Zhang1, Hong-Xiang Yu1, Nan Zhi2, Can Cui2, Ying-Ying Han2, Min Hu2, Hao Shen1, Huan Bao1, Gang Li1. 1. Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China. 2. Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Abstract
STUDY OBJECTIVES: To discover the associations between HMOX-1 and Alzheimer's disease (AD). METHODS: 500 AD patients and 500 healthy controls were recruited in this study. Polymer chain reaction (PCR) was used. RESULTS: The dominant model and the recessive model of HMOX-1 rs2071746 were shown statistically significant between AD patients and control after adjustment of age, gender and education (Dominant model: p value: 0.047, OR: 1.34, 95% CI: 1.00 - 1.78, adjusted; recessive model: p value: 0.049, OR: 1.34, 95% CI: 1.00 - 1.80, adjusted). There is also a trend of association between dominant model and LOAD after adjustment of age, gender and education (Dominant model: p value: 0.084, OR: 1.37, 95% CI: 0.96 - 1.95, adjusted). CONCLUSIONS: We found the association of the dominant model and the recessive model of HMOX1 rs2071746 with AD. This article is protected by copyright. All rights reserved.
STUDY OBJECTIVES: To discover the associations between HMOX-1 and Alzheimer's disease (AD). METHODS: 500 ADpatients and 500 healthy controls were recruited in this study. Polymer chain reaction (PCR) was used. RESULTS: The dominant model and the recessive model of HMOX-1rs2071746 were shown statistically significant between ADpatients and control after adjustment of age, gender and education (Dominant model: p value: 0.047, OR: 1.34, 95% CI: 1.00 - 1.78, adjusted; recessive model: p value: 0.049, OR: 1.34, 95% CI: 1.00 - 1.80, adjusted). There is also a trend of association between dominant model and LOAD after adjustment of age, gender and education (Dominant model: p value: 0.084, OR: 1.37, 95% CI: 0.96 - 1.95, adjusted). CONCLUSIONS: We found the association of the dominant model and the recessive model of HMOX1rs2071746 with AD. This article is protected by copyright. All rights reserved.
Entities:
Keywords:
Alzheimer’s disease; HMOX-1; genetic associations; late onset Alzheimer’s disease; single nucleotide polymorphism