Literature DB >> 33864153

Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial.

Dolors Rodríguez-Pardo1,2,3, María Dolores Del Toro4,5,6, Laura Guío-Carrión4,5,7, Rosa Escudero-Sánchez5,8, Marta Fernández-Sampedro4,5,9, Miguel Ángel García-Viejo5,10, María Velasco-Arribas5,11, Laura Soldevila-Boixader5,12, Magdalena Femenias13, José Antonio Iribarren5,14, María Del Carmen Pulido-Garcia15, María Dolores Navarro4,5,6, Mayli Lung4,5,16, Pablo S Corona4,5,17, Benito Almirante18,4,5, Carles Pigrau18,4,5.   

Abstract

PURPOSE: To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture.
METHODS: Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB. PRIMARY OUTCOME: early-PJI after HHA.
RESULTS: Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin-trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33-3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15-7.10]).
CONCLUSIONS: Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47.
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Entities:  

Keywords:  Asymptomatic bacteriuria; Early-periprosthetic joint infection; Fosfomycin-trometamol; Hip hemiarthroplasty

Mesh:

Substances:

Year:  2021        PMID: 33864153     DOI: 10.1007/s10096-021-04241-2

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN: 0934-9723            Impact factor:   3.267


  15 in total

Review 1.  The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials.

Authors:  D Moher; K F Schulz; D G Altman
Journal:  Ann Intern Med       Date:  2001-04-17       Impact factor: 25.391

Review 2.  Prosthetic-joint infections.

Authors:  Werner Zimmerli; Andrej Trampuz; Peter E Ochsner
Journal:  N Engl J Med       Date:  2004-10-14       Impact factor: 91.245

3.  [Is it necessary to delay or to put off surgery in the case of possible asymptomatic bacteriuria and orthopaedic surgery with implants?].

Authors:  Iñaki Otermin; María Rivero; Angel Hidalgo
Journal:  Enferm Infecc Microbiol Clin       Date:  2009-02-26       Impact factor: 1.731

4.  Are antibiotics necessary in hip arthroplasty with asymptomatic bacteriuria? Seeding risk with/without treatment.

Authors:  José Cordero-Ampuero; Enrique González-Fernández; David Martínez-Vélez; Jaime Esteban
Journal:  Clin Orthop Relat Res       Date:  2013-12       Impact factor: 4.176

5.  Preoperative urine cultures at a veterans affairs medical center.

Authors:  Dimitri M Drekonja; Breanna Zarmbinski; James R Johnson
Journal:  JAMA Intern Med       Date:  2013-01-14       Impact factor: 21.873

6.  What are the risk factors for infection in hemiarthroplasties and total hip arthroplasties?

Authors:  José Cordero-Ampuero; Marisol de Dios
Journal:  Clin Orthop Relat Res       Date:  2010-12       Impact factor: 4.176

Review 7.  Perioperative lower urinary tract infections and deep sepsis in patients undergoing total joint arthroplasty.

Authors:  T S David; M S Vrahas
Journal:  J Am Acad Orthop Surg       Date:  2000 Jan-Feb       Impact factor: 3.020

8.  Is asymptomatic bacteriuria a risk factor for prosthetic joint infection?

Authors:  Ricardo Sousa; Ernesto Muñoz-Mahamud; Jonathan Quayle; Luis Dias da Costa; Cristina Casals; Phylip Scott; Pedro Leite; Paz Vilanova; Sebastian Garcia; Maria Helena Ramos; Joana Dias; Alex Soriano; Andrea Guyot
Journal:  Clin Infect Dis       Date:  2014-04-09       Impact factor: 9.079

Review 9.  Periprosthetic fractures around hip hemiarthroplasty performed for hip fracture.

Authors:  J R A Phillips; C G Moran; A R J Manktelow
Journal:  Injury       Date:  2012-10-25       Impact factor: 2.586

10.  Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America.

Authors:  Lindsay E Nicolle; Kalpana Gupta; Suzanne F Bradley; Richard Colgan; Gregory P DeMuri; Dimitri Drekonja; Linda O Eckert; Suzanne E Geerlings; Béla Köves; Thomas M Hooton; Manisha Juthani-Mehta; Shandra L Knight; Sanjay Saint; Anthony J Schaeffer; Barbara Trautner; Bjorn Wullt; Reed Siemieniuk
Journal:  Clin Infect Dis       Date:  2019-05-02       Impact factor: 9.079

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  1 in total

Review 1.  Recurrent Urinary Tract Infections and Asymptomatic Bacteriuria in Adults.

Authors:  David Hernández-Hernández; Bárbara Padilla-Fernández; María Yanira Ortega-González; David Manuel Castro-Díaz
Journal:  Curr Bladder Dysfunct Rep       Date:  2021-12-01
  1 in total

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