Literature DB >> 33863824

The Latest Advances in Imaging Crosstalk Between the Immune System and Fibrosis in Cardiovascular Disease.

Gyu Seong Heo1, Lanlan Lou1, Deborah Sultan1, Yongjian Liu2.   

Abstract

Inflammation and fibrosis are hallmarks of tissue repair processes and organ failure progression in cardiovascular diseases. Paradigm-shifting research on diverse immune cell populations within the cardiovascular system have enabled discovery of new biomarkers fostering development of diagnostic and therapeutic agents at the molecular level to better manage cardiovascular diseases. To date, a variety of molecular imaging agents have been developed to visualize the biomarkers expressed on immune cells and fibroblasts within their crosstalk network, which drives the pathogenesis of fibrosis triggered by both innate and adaptive immunity. Herein, key biomarkers upregulated in the immune-fibrosis axis are discussed. The promising molecular imaging agents to reveal this critical pathologic process are summarized.
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Entities:  

Keywords:  cardiovascular diseases; fibrosis; immune system; inflammation; molecular imaging

Mesh：

Year:  2021        PMID： 33863824      PMCID： PMC8724900          DOI： 10.2967/jnumed.120.255539

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  39 in total

Review 1.  Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.

Authors:  Gyu S Heo; Deborah Sultan; Yongjian Liu
Journal:  Q J Nucl Med Mol Imaging       Date:  2020-02-18       Impact factor: 2.346

Review 2.  Radionuclide Image-Guided Repair of the Heart.

Authors:  Annika Hess; James T Thackeray; Kai C Wollert; Frank M Bengel
Journal:  JACC Cardiovasc Imaging       Date:  2019-12-18

3.  Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4.

Authors:  Annika Hess; Thorsten Derlin; Tobias Koenig; Johanna Diekmann; Alexander Wittneben; Yong Wang; Hans-Juergen Wester; Tobias L Ross; Kai C Wollert; Johann Bauersachs; Frank M Bengel; James T Thackeray
Journal:  Eur Heart J       Date:  2020-10-01       Impact factor: 29.983

Review 4.  Matrix Metalloproteinases in Myocardial Infarction and Heart Failure.

Authors:  Kristine Y DeLeon-Pennell; Cesar A Meschiari; Mira Jung; Merry L Lindsey
Journal:  Prog Mol Biol Transl Sci       Date:  2017-03-18       Impact factor: 3.622

5.  The Latest Developments in Imaging of Fibroblast Activation Protein.

Authors:  Annette Altmann; Uwe Haberkorn; Jens Siveke
Journal:  J Nucl Med       Date:  2020-10-30       Impact factor: 10.057

Review 6.  Type 2 immunity in tissue repair and fibrosis.

Authors:  Richard L Gieseck; Mark S Wilson; Thomas A Wynn
Journal:  Nat Rev Immunol       Date:  2017-08-30       Impact factor: 53.106

Review 7.  Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation.

Authors:  Andrew A Gibb; Michael P Lazaropoulos; John W Elrod
Journal:  Circ Res       Date:  2020-07-16       Impact factor: 17.367

Review 8.  Molecular Probes for Imaging Fibrosis and Fibrogenesis.

Authors:  Pauline Désogère; Sydney B Montesi; Peter Caravan
Journal:  Chemistry       Date:  2018-11-21       Impact factor: 5.236

Review 9.  Inflammation and metabolism in tissue repair and regeneration.

Authors:  Sabine A Eming; Thomas A Wynn; Paul Martin
Journal:  Science       Date:  2017-06-08       Impact factor: 47.728

10.  Molecular Imaging of Factor XIII Activity for the Early Detection of Mouse Coronary Microvascular Disease.

Authors:  Zhen W Zhuang; Yang Huang; Rong Ju; Mark W Maxfield; Yongming Ren; Xiangning Wang; Xinlu Wang; Mitchel R Stacy; John Hwa
Journal:  Theranostics       Date:  2019-02-20       Impact factor: 11.556
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