Literature DB >> 33863618

Cellular senescence in pathologic retinal angiogenesis.

Zhongjie Fu1, Lois E H Smith2.   

Abstract

Pathologic angiogenesis causes blindness in many eye diseases. Crespo-Garcia, Tsuruda, and Dejda et al. employed bioinformatics to characterize cell senescence as a primary factor in the common pathogenesis of retinopathies. They validated their findings using human and mouse retina with proliferative retinopathy. Clearance of senescent cells suppressed neovessel growth.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  endothelial cells; metabolism; neovascularization; retinal angiogenesis; senescence

Mesh：

Year:  2021        PMID： 33863618      PMCID： PMC8612461          DOI： 10.1016/j.tem.2021.03.010

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  10 in total

Review 1.  Endothelial Cell Metabolism.

Authors:  Guy Eelen; Pauline de Zeeuw; Lucas Treps; Ulrike Harjes; Brian W Wong; Peter Carmeliet
Journal:  Physiol Rev       Date:  2018-01-01       Impact factor: 37.312

2.  Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Authors:  Malika Oubaha; Khalil Miloudi; Agnieszka Dejda; Vera Guber; Gaëlle Mawambo; Marie-Anne Germain; Guillaume Bourdel; Natalija Popovic; Flavio A Rezende; Randal J Kaufman; Frédérick A Mallette; Przemyslaw Sapieha
Journal:  Sci Transl Med       Date:  2016-10-26       Impact factor: 17.956

3.  mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

Authors:  Chen Zhao; Douglas Yasumura; Xiyan Li; Michael Matthes; Marcia Lloyd; Gregory Nielsen; Kelly Ahern; Michael Snyder; Dean Bok; Joshua L Dunaief; Matthew M LaVail; Douglas Vollrath
Journal:  J Clin Invest       Date:  2010-12-06       Impact factor: 14.808

4.  Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration.

Authors:  Janos Feher; Illes Kovacs; Marco Artico; Carlo Cavallotti; Antonio Papale; Corrado Balacco Gabrieli
Journal:  Neurobiol Aging       Date:  2005-06-23       Impact factor: 4.673

5.  Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.

Authors:  Sergio Crespo-Garcia; Pamela R Tsuruda; Agnieszka Dejda; Rathi D Ryan; Frederik Fournier; Shawnta Y Chaney; Frederique Pilon; Taner Dogan; Gael Cagnone; Priyanka Patel; Manuel Buscarlet; Sonali Dasgupta; Gabrielle Girouard; Surabhi R Rao; Ariel M Wilson; Robert O'Brien; Rachel Juneau; Vera Guber; Alexandre Dubrac; Christian Beausejour; Scott Armstrong; Frederick A Mallette; Christopher B Yohn; Jean-Sebastien Joyal; Dan Marquess; Pedro J Beltran; Przemyslaw Sapieha
Journal:  Cell Metab       Date:  2021-02-05       Impact factor: 27.287

6.  Photoreceptor glucose metabolism determines normal retinal vascular growth.

Authors:  Zhongjie Fu; Chatarina A Löfqvist; Raffael Liegl; Zhongxiao Wang; Ye Sun; Yan Gong; Chi-Hsiu Liu; Steven S Meng; Samuel B Burnim; Ivana Arellano; My T Chouinard; Rubi Duran; Alexander Poblete; Steve S Cho; James D Akula; Michael Kinter; David Ley; Ingrid Hansen Pupp; Saswata Talukdar; Ann Hellström; Lois Eh Smith
Journal:  EMBO Mol Med       Date:  2018-01       Impact factor: 12.137

7.  Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.

Authors:  Jean-Sébastien Joyal; Ye Sun; Marin L Gantner; Zhuo Shao; Lucy P Evans; Nicholas Saba; Thomas Fredrick; Samuel Burnim; Jin Sung Kim; Gauri Patel; Aimee M Juan; Christian G Hurst; Colman J Hatton; Zhenghao Cui; Kerry A Pierce; Patrick Bherer; Edith Aguilar; Michael B Powner; Kristis Vevis; Michel Boisvert; Zhongjie Fu; Emile Levy; Marcus Fruttiger; Alan Packard; Flavio A Rezende; Bruno Maranda; Przemyslaw Sapieha; Jing Chen; Martin Friedlander; Clary B Clish; Lois E H Smith
Journal:  Nat Med       Date:  2016-03-14       Impact factor: 53.440

8.  Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.

Authors:  Mark A Kanow; Michelle M Giarmarco; Connor Sr Jankowski; Kristine Tsantilas; Abbi L Engel; Jianhai Du; Jonathan D Linton; Christopher C Farnsworth; Stephanie R Sloat; Austin Rountree; Ian R Sweet; Ken J Lindsay; Edward D Parker; Susan E Brockerhoff; Martin Sadilek; Jennifer R Chao; James B Hurley
Journal:  Elife       Date:  2017-09-13       Impact factor: 8.140

Review 9.  The Emerging Role of Senescence in Ocular Disease.

Authors:  Parameswaran G Sreekumar; David R Hinton; Ram Kannan
Journal:  Oxid Med Cell Longev       Date:  2020-03-09       Impact factor: 6.543
  10 in total
  1 in total

1.  Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

Authors:  Parameswaran G Sreekumar; Srinivasa T Reddy; David R Hinton; Ram Kannan
Journal:  Exp Eye Res       Date:  2022-01-02       Impact factor: 3.467
  1 in total

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