Priscilla Roberta Silva Rocha1, Valdiane Dutra Oliveira2, Christiane Inocêncio Vasques3, Paula Elaine Diniz Dos Reis3, Angélica Amorim Amato4. 1. Faculty of Ceilândia, University of Brasília, Campus Universitário s/n, Metropolitan Center, Brasília, DF, 72220-275, Brazil. Electronic address: priscillarocha@unb.br. 2. HOME Hospital, SGAS 613, Asa Sul, Brasília, DF, 70200-730, Brazil. 3. Nursing Department, School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil. 4. Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.
Abstract
AIM: The aim of this study was to investigate the association between human exposure to endocrine disruptors (EDs) and the risk of breast cancer. METHODS: This was a systematic review conducted by searching Cochrane Library, LILACS, Livivo, PubMed, and Science Direct. Observational studies addressing the association between exposure to EDs and breast cancer risk in adults were included. Risk of bias was assessed using the National Toxicology Program's Office of Health Assessment Translation tool. RESULTS: a total of 37 studies were included. Most studies reported that exposure to organochlorine pesticides, phthalates, heavy metals, and polycyclic aromatic hydrocarbons was associated with increased breast cancer risk. CONCLUSION: qualitative analysis of observational studies indicates that human exposure to EDs is associated with increased breast cancer risk. Additional studies are needed to determine whether this association is causal.
AIM: The aim of this study was to investigate the association between human exposure to endocrine disruptors (EDs) and the risk of breast cancer. METHODS: This was a systematic review conducted by searching Cochrane Library, LILACS, Livivo, PubMed, and Science Direct. Observational studies addressing the association between exposure to EDs and breast cancer risk in adults were included. Risk of bias was assessed using the National Toxicology Program's Office of Health Assessment Translation tool. RESULTS: a total of 37 studies were included. Most studies reported that exposure to organochlorine pesticides, phthalates, heavy metals, and polycyclic aromatic hydrocarbons was associated with increased breast cancer risk. CONCLUSION: qualitative analysis of observational studies indicates that human exposure to EDs is associated with increased breast cancer risk. Additional studies are needed to determine whether this association is causal.
Authors: Diana C Pacyga; Brad A Ryva; Romana A Nowak; Serdar E Bulun; Ping Yin; Zhong Li; Jodi A Flaws; Rita S Strakovsky Journal: Int J Environ Res Public Health Date: 2022-02-26 Impact factor: 3.390