Late Local Recurrence and Metastasis in Soft Tissue Sarcoma of the Extremities and Trunk Wall: Better Outcome After Treatment of Late Events Compared with Early.

BACKGROUND: Approximately 80% of soft tissue sarcoma (STS) recurrences, local and metastatic disease, are diagnosed within the first 3 years after primary diagnosis and treatment. Recurrences, however, can present after a longer period of remission. Our goal was to identify factors that may predict the risk of late recurrence.
METHODS: We identified 677 patients with STS of the extremities and trunk wall from a population-based sarcoma register. Of these, 377 patients were alive and event-free at 3 years and were included for analysis of possible risk factors for late recurrence.
RESULTS: Fifty-five of 377 (15%) patients developed late recurrence: 23 local recurrence, 21 metastasis, and 11 both manifestations. With R0 wide surgical margin as reference, R0 marginal (hazard ratio [HR] 2.6; p = 0.02) and R1 (HR 5.0; p = 0.005) margins were risk factors for late local recurrence. Malignancy grade (HR 8.3; p = 0.04) and R0 marginal surgical margin (HR 2.3; p = 0.04) were risk factors for late metastasis. We could not find a statistically significant correlation of late recurrence with many of the generally known risk factors for local recurrence and metastasis in STS. Outcome after treatment of late recurrences was better compared with outcome after treatment of early events.
CONCLUSIONS: Late recurrences, albeit relatively rare, do occur. Outcome after treatment was good compared with outcome after early events. Long surveillance of all patients with high-grade STS, especially if R0 wide surgical margin is not achieved in the primary treatment, appear to be well justified.

Soft tissue sarcomas (STS) of the extremities and trunk wall constitute a heterogenous group of malignant tumors comprising more than 50 histological subtypes.1 In mixed series of STS the 5-year disease-free survival is approximately two-thirds, with specific metastasis-free and local recurrence-free survival rates of approximately 70% and 80%, respectively.2,3 Metastatic disease, most common to the lungs, is generally associated with a poor prognosis.4

Several prognostic factors that correlate with risk for local recurrence (LR) and distant metastasis (DM) have been identified, e.g., malignancy grade, size, tumor depth, surgical margins, certain histological subtypes, and tumor characteristics.5–7 Staging systems from AJCC and UICC include malignancy grade, tumor size, metastatic disease, or lymph node engagement but have limited value for treatment decisions in clinical practice.5,6,8–10 In Sweden, the SING system is used to identify high-risk tumors. The SING system includes assessment of tumor size, vascular invasion, tumor necrosis, and growth pattern in high-grade tumors.11–13

After primary treatment, follow-up surveillance includes physical examination and imaging of the chest. MRI of the primary tumor site is performed when indicated. The objective of standardized follow-up routines is to identify recurrences early in order to improve the chances of remission and long-term survival.5 ESMO and Swedish guidelines recommend follow-up for 10 years with intervals depending on malignancy grade.5,14 Approximately 80% of relapses after primary treatment occur within the first 3 years.3,5,15–17 Risk factors for late recurrence are not well studied, and it has been suggested that the prognostic value of known risk factors diminish over time.18–21

The purpose of this study was to investigate the STS recurrence pattern, LR and/or DM, over time and identify possible risk factors and predictors for late tumor recurrence. We have evaluated patients who were event-free and alive 3 years after primary diagnosis. Late recurrence often is defined as a recurrence diagnosed later than 5 years after the primary diagnosis and treatment.19,20,22 We have chosen 3 years as a cutoff, because we believe that it better reflects the recurrence pattern of STS (see Discussion). Prognostic factors for late LR and late DM, respectively, were evaluated with the goal to investigate whether it is possible to identify which patients would or would not benefit from a long surveillance.

Methods

We identified adult patients (>18 years) with primary STS of the extremities and trunk wall, diagnosed between 1986 and 2014 in the Southern Sweden healthcare region (1.8 million inhabitants), using the national sarcoma quality register.2,23–25 Patients have prospectively been enrolled in the register, which has complete coverage compared with the national cancer register. Patients who were not surgically treated, patients with DM at diagnosis and certain histological subtypes (e.g., rhabdomyosarcoma, Ewing’s sarcoma of soft tissue, dermatofibrosarcoma protuberans, and atypical lipomatous tumor) were excluded. The register includes data on diagnosis, treatment, and outcome. In addition to register data, clinical charts were reviewed.

Patients were followed according to the Swedish and ESMO guidelines with physical examination and chest imaging. High-grade tumors were followed every third month for the first 3 years, twice per year up to 5 years, and once per year thereafter. Low-grade tumors were followed twice per year the first 5 years, and thereafter annually. Patients with first recurrence within 3 years were considered to have an early recurrence and patients with first recurrence at 3 years or later were considered to have a late recurrence. Patients with early recurrence were analyzed for reference purpose (supplementary tables).

Tumor size was determined as the largest diameter on histopathologic examination and was dichotomized at both 5 and 8 cm as these cutoffs are commonly used in other studies; 8 cm is used in the Swedish guidelines to identify high-risk tumors. Vascular invasion was defined as presence of tumor cells within any space with endothelial lining. Both vascular invasion and microscopic necrosis were classified as present or not and peripheral growth pattern as pushing or infiltrative.11,12 Tumors were classified as either superficial, if strictly located above an unengaged fascia, or deep-seated if the fascia was invaded or the tumor was located deep to the fascia. The FNCLCC histologic grading system is currently used in the clinical setting at our center. However, a large part of our series was graded using the Broders’ four-tiered system that was used before the French grading system was introduced.26 Low grade (grade 1 and 2) translates approximately to FNCLCC grade 1 and high grade (grades 3 and 4) to FNCLCC grade 2 and 3. Surgical margin was, in accordance with Swedish guidelines, classified as R0 wide if the tumor was surrounded by a 10-mm cuff of healthy fatty, muscular, or loose areolar tissue or an unengaged fascia.27,28 The margin was classified as R0 marginal if there was less than 10-mm margin or engagement of the fascia, as R1 (intralesional) if there was microscopic growth at the resection margin, or as R2 if there was macroscopic residual tumor.29,30 In cases with more than one surgical procedure performed for the primary tumor, the margin obtained at the last surgery was recorded as final margin.

The study was approved by the Lund University Ethics Committee and meet the guidelines of their responsible governmental agency.

Statistical Analysis

Statistical analysis was performed using log-rank test or Cox proportional hazard model and survival data visualized using Kaplan–Meier survival analysis. Only variables that were statistically significant in univariable analysis were included in the multivariable analysis, because the number of events would not allow all variables to be included. A global significance test was calculated using likelihood ratio test. Time to event was calculated from the date of initial diagnosis to the recurrence date. Patients were censored at the last follow-up with no evidence of disease or at death without tumor. Survival was analyzed from diagnosis date or recurrence date to death or until censored. A p value < 0.05 was considered statistically significant. Statistical analysis was performed using Stata/IC 15.1 for Mac (StataCorp LLC, TX).

Results

A total of 877 STS patients were identified of which 43 patients were excluded for not being surgically treated and 81 for having DM at the time of diagnosis. Another 61 cases were excluded due to certain histological subtypes, and 13 cases were lost to follow-up within 3 years. Two patients had insufficient data and were excluded. The remaining 677 patients were included in the study.

Of these 677 patients, 250 (37%) had recurrence within the first 3 years from initial diagnosis: 60 patients had LR, 121 had DM, and 69 had both LR and DM. Another 50 patients without recurrence died within 3 years (mean age 81 years). The event-free survival for each year is presented in Table 1 and Fig. 1a. The 5-year overall survival (OS) was 63% (95% confidence interval [CI] 59–66), and the 10-year OS was 46% (95% CI 42–50) for these 677 patients.

Table 1

Event-free survival and cumulative number of events at the end of each interval from diagnosis of soft tissue sarcoma

Interval (years)	Event-free survival (95% CI)	No. at risk at beginning of interval	Cumulative number of events	Cumulative percentage of events	Recurrence hazard rate (SE)
0 to 1	78 (75–81)	677	147	48%	0.021 (0.0017)
1 to 2	67 (63–71)	506	217	71%	0.013 (0.0015)
2 to 3	62 (58–65)	426	250	82%	0.007 (0.0012)
3 to 4	59 (55–63)	377	265	87%	0.004 (0.0009)
4 to 5	57 (53–61)	333	277	91%	0.003 (0.0009)
5 to 6	55 (51–59)	285	287	94%	0.003 (0.001)
6 to 7	54 (50–58)	229	290	95%	0.001 (0.0007)
7 to 8	53 (49–57)	181	293	96%	0.002 (0.0009)
8 to 9	52 (47–56)	155	297	97%	0.002 (0.0012)
9 to 10	51 (47–55)	128	298	98%	0.001 (0.0007)
10 to 14	46 (41–51)	110	305	100%

Fig. 1

a Event-free survival from date of diagnosis of soft tissue sarcoma. b Survival in months from date of local recurrence for early and late recurrence (log-rank test). c Survival in months from date of metastatic disease for early and late recurrence (log-rank test)

Event-Free at 3 Years

Patient and tumor characteristics for the 377 patients that were event-free and alive at 3 years from diagnosis are further described in Table 2. Seventy-seven percent of these tumors were high-grade, and the most common histological subtypes were undifferentiated pleomorphic sarcoma (21%), leiomyosarcoma (21%), and myxofibrosarcoma (18%). Less frequent subtypes (n < 10) were grouped for analysis. Of the STS located in the extremities, 96% underwent limb-sparing surgery for the primary tumor. The median age at diagnosis was 64 years (mean 60; range 18–96) with slight male predominance (57%). Median tumor size was 6 cm (mean 7; range 1–28). Ninety-two percent (95% CI 88.9–94.6) and 83% (95% CI 77.6–87.1) of these patients were still event-free at 5 and 10 years from diagnosis, respectively. The median follow-up time was 7.7 years (mean 9.1; range 3–26).

Table 2

Overview of patients and tumor characteristics

Characteristic	n = 377	%
Median age at diagnosis in years (mean; range)	64 (60; 18–96)
Male	214	57
Female	163	43
Tumor depth (n, %)
Superficial	175	47
Deep	196	53
Not available	6
Tumor site (n, %)
Upper trunk	29	8
Lower trunk	15	4
Shoulder	18	5
Upper arm	36	9
Elbow	11	3
Lower arm	30	8
Hand	5	1
Gluteal	23	6
Groin	11	3
Thigh	136	36
Knee	11	3
Lower leg	38	10
Foot	14	4
Median tumor diameter in cm (mean; range)	6 (7; 1–28)
Tumor grade (n, %)
1	24	7
2	55	16
3	71	20
4	201	57
Not available	26
Vascular invasion
Yes	38	12
No	273	88
Not available	66
Necrosis
Yes	167	52
No	157	48
Not available	53
Growth pattern
Pushing	20	19
Infiltrative	88	81
Not available	269
Histologic subtype (n, %)
Undifferentiated pleomorphic sarcoma	78	21
Myxofibrosarcoma	68	18
Liposarcoma	47	12
Leiomyosarcoma	81	21
Synovial sarcoma	19	5
Malignant peripheral nerve sheath tumor	18	5
Other typea	66	18
Surgical procedure (n, %)b
Limb salvage	321	96
Amputation	12	4
Surgical margin (n, %)
R0 wide	252	67
R0 marginal	109	29
R1	15	4
R2	0	0
Not available	1
Radiotherapy
Yes	129	34
No	248	66
Chemotherapy
Yes	45	12
No	332	88

aAlveolar soft part sarcoma, clear cell sarcoma, epithelioid sarcoma, low-grade fibromyxoid sarcoma, solitary fibrous tumor, fibrosarcoma, unclassified sarcoma and angiosarcoma

bNot applicable to the 44 patients with tumors located to the trunk wall

Late recurrence was diagnosed in 55 (15%) of the 377 patients who were free from disease and alive at 3 years from diagnosis, or 8% of the initial cohort of 677 patients. LR was recorded in 23 patients, DM in 21 patients, and both LR and DM in 11 patients.

Late Local Recurrence

Late LR was recorded in 34 of the 377 patients. The median time to late LR was 5 years (mean 5.8; range 3–13) from diagnosis. R0 marginal (HR 3.3; p = 0.001) or R1 surgical margin (HR 5.4; p = 0.003) and radiotherapy (HR 2.3; p = 0.015) revealed statistically significant correlations with late LR using univariable analysis. None of the 19 patients with synovial sarcoma developed late LR (Table 3). When multivariable analysis was performed, R1 (HR 5.0; p = 0.005) and R0 marginal (HR 2.6; p = 0.02) surgical margins were independently associated with late LR, while radiotherapy was not (Table 4). Age, sex, malignancy grade, histological subtype, tumor site, depth, chemotherapy, and the SING factors (size, vascular invasion, necrosis, and peripheral growth pattern) did not reveal any statistically significant correlation with late LR.

Table 3

Univariable Cox proportional hazard model analysis of prognostic factors for late local recurrences

	Patients	Local recurrence	%	HR	95% CI	p value	p value b
Age (year)
< 64	183	16	8.7	Reference
≥ 64	194	18	9.3	1.2	0.6–2.4	0.58	0.58
Sex
Male	214	21	9.8	Reference
Female	163	13	8.0	0.8	0.4–1.6	0.48	0.48
Depth
Superficial	175	16	9.1	Reference
Deep	196	18	9.2	0.8	0.4–1.7	0.63	0.63
Not available	6	0
Location
Lower extremity	233	24	10	Reference
Upper extremity	100	6	6.0	0.6	0.2–1.4	0.25
Trunk	44	4	9.1	0.9	0.3–2.5	0.82	0.48
Size (cm)
< 5	144	10	6.9	Reference
≥ 5	229	22	9.6	1.3	0.6–2.8	0.46	0.45
Not available (cm)	4	2
< 8	244	16	6.6	Reference
≥ 8	129	16	12	1.9	0.9–3.7	0.08	0.08
Not available	4	2
Malignancy grade
Low-grade	81	5	6.2	Reference
High-grade	282	28	10	1.6	0.6–4.2	0.32	0.30
Not available	14	1
Vascular invasion
No	273	21	7.7	Reference
Yes	38	4	11	1.4	0.5–4	0.55	0.57
Not available	66	9
Necrosis
No	157	13	8.3	Reference
Yes	167	14	8.4	1.1	0.5–2.3	0.81	0.81
Not available	53	7
Growth pattern
Pushing	20	2	10	Reference
Infiltrative	88	7	8.0	0.8	0.2–3.9	0.76	0.76
Not available	269	25
Histology
UPS	78	10	13	Reference
Leiomyosarcoma	81	4	4.9	0.4	0.1–1.4	0.16
Liposarcoma	47	3	6.4	0.5	0.1–1.9	0.31
MPNST	18	3	17	1.0	0.3–4	0.90
Myxofibrosarcoma	68	8	12	0.8	0.5–3.2	0.63
Synovial sarcoma	19	0	0	–*
Other	66	6	9.1	0.7	0.3–2.1	0.60	0.15
Surgical procedure a
Local excision	321	30	9.3	Reference
Amputation	12	0	0	–
Final surgical margin
R0 wide	252	13	5.2	Reference
R0 marginal	109	16	15	3.3	1.6–6.8	0.001
R1	15	4	27	5.4	1.8–16.6	0.003	0.001
Not available	1	1
Radiotherapy
No	248	18	7.3	Reference
Yes	129	16	12	2.3	1.2–4.6	0.015	0.017
Chemotherapy
No	332	30	9.0	Reference
Yes	45	4	8.9	1.4	0.5–4.0	0.55	0.56

UPS undifferentiated pleomorphic sarcoma; MPNST malignant peripheral nerve sheath tumor

aNot applicable to the 44 patients with tumors located to the trunk wall

bOverall likelihood ratio test

Table 4

Multivariable Cox proportional hazard model analysis of prognostic factors for late recurrence

	Late local recurrence				Late metastasis
	HR	95% CI	p value	p valuec	HR	95% CI	p value	p valuec
Size (cm)
< 5					Reference
≥ 5					2.6	0.9–7.7	0.09	0.09
Not available
Malignancy grade
Low-grade					Referencea
High-grade					8.3	1.1–61	0.04	0.04
Not available
Vascular invasion
No					Reference
Yes					1.1	0.4–2.9	0.82	0.82
Not available
Final surgical margin
R0 wide	Reference				Referenceb
R0 marginal	2.6	1.1–6.1	0.02		2.3	1–5.2	0.04
R1	5.0	1.6–16	0.005	0.009	1.4	0.2–11	0.73	0.065
Not available
Radiotherapy
No	Reference
Yes	1.6	0.7–3.4	0.27	0.27

aVascular invasion was left out when analyzing malignancy grade due to missing values violating the analysis

bTumor size was left out when analyzing R1 intralesional surgical margin due to missing values violating the analysis

cOverall likelihood ratio test

The LR were treated with local excision in 29 cases (85%) and amputation in 4 cases (12%). One patient with late LR was not surgically treated due to severe comorbidity.

The LR were identified by the patient in-between clinical visits in 17 cases, on clinical follow-up visits in 7 cases, and in 3 cases by MRI performed of the primary tumor site, due to unspecified local symptoms. Data were not available in 7 cases.

The 3- and 5-year OS from the date of late LR was 77% (95% CI 58–88) and 63% (95% CI 43–78), respectively, compared with 45% (95% CI 36–53) and 40% (95% CI 31–48) for those with an early LR (p = 0.01; Fig. 1b).

Late Metastasis

Late DM was recorded in 32 of the 377 patients. The median time to late DM was 6.2 years (mean 7.1; range 3–13) from diagnosis of the primary tumor. For patients with both late LR and DM, the DM were identified at a median of 31 months (mean 41; range 4–95) after the preceding late LR.

Univariable statistical analysis showed that late DM was associated with high malignancy grade (HR 4.6; p = 0.04), size ≥5 cm (HR 3; p = 0.003), and vascular invasion (HR 2.9; p = 0.01) (Table 5). A statistically significant correlation was also seen with R0 marginal margin (HR 2.2; p = 0.04) but not with R1 margin (HR 1.7; p = 0.48), resulting in a nonsignificant global significance test (p = 0.11). The multivariable analysis revealed that high malignancy grade (HR 8.3; p = 0.04) was independently correlated with risk of late DM. This also was observed for R0 marginal margin (HR 2.3; p = 0.04), but the global significance test was nonsignificant (p = 0.065; Table 4). We could not find any statistical correlations between late DM and age, sex, histological subtype, tumor size dichotomized at 8 cm, tumor site, depth, surgical procedure, tumor necrosis, peripheral growth pattern, radiotherapy, or chemotherapy.

Table 5

Univariable Cox proportional hazard model analysis of prognostic factors for late metastasis

	Patients	Metastasis	%	HR	95% CI	p value	p valueb
Age (year)
< 64	183	26	8.7	Reference
≥ 64	194	16	8.2	1.1	0.6–2.3	0.71	0.71
Sex
Male	214	19	8.9	Reference
Female	163	13	8.0	0.9	0.4–1.8	0.70	0.70
Depth
Superficial	175	13	7.4	Reference
Deep	196	19	9.7	1.0	0.5–2	0.90	0.90
Not available	6	0
Location
Lower extremity	233	21	9.0	Reference
Upper extremity	100	7	7.0	0.8	0.4–2	0.69
Trunk	44	4	9.1	1.0	0.3–2.9	0.99	0.92
Size (cm)
< 5	144	5	3.5	Reference
≥ 5	229	25	11	3.0	1.2–7.9	0.03	0.01
Not available (cm)	4	2
< 8	244	17	7.0	Reference
≥ 8	129	13	10	1.4	0.7–2.8	0.40	0.41
Not available	4	2
Malignancy grade
Low-grade	81	2	2.5	Reference
High-grade	282	29	11	4.6	1.1–19	0.04	0.009
Not available	14	1
Vascular invasion
No	273	20	7.3	Reference
Yes	38	8	21	2.9	1.3–6.7	0.01	0.02
Not available	66	4
Necrosis
No	157	12	7.6	Reference
Yes	167	16	9.6	1.4	0.7–3	0.35	0.35
Not available	53	4
Growth pattern
Pushing	20	2	10	Reference
Infiltrative	88	3	3.4	0.4	0.1–2.2	0.27	0.29
Not available	269	27
Histology
UPS	78	9	12	Reference
Leiomyosarcoma	81	7	8.6	1.0	0.4–2.7	0.97
Liposarcoma	47	1	2.1	0.2	0–1.5	0.12
MPNST	18	3	17	1.2	0.3–4.4	0.80
Myxofibrosarcoma	68	3	4.4	0.6	0.2–2.2	0.43
Synovial sarcoma	19	1	5.3	0.4	0.1–3.2	0.40
Other	66	8	12	1.3	0.5–3.5	0.56	0.32
Surgical procedurea
Local excision	321	27	8.4	Reference
Amputation	12	1	8.3	0.7	0.1–5.5	0.77	0.76
Final surgical margin
R0 Wide	252	16	6.3	Reference
R0 Marginal	109	14	13	2.2	1.1–4.4	0.04
R1	15	2	13	1.7	0.4–7.4	0.48	0.11
Not available	1	0
Radiotherapy
No	248	21	8.5	Reference
Yes	129	11	8.5	1.4	0.7–2.9	0.37	0.38
Chemotherapy
No	332	27	8.1	Reference
Yes	45	5	11	2.5	0.9–6.6	0.07	0.10

UPS undifferentiated pleomorphic sarcoma; MPNST malignant peripheral nerve sheath tumor

aNot applicable to the 44 patients with tumors located to the trunk wall

bOverall likelihood ratio test

The 3- and 5-year OS from the date of late DM were 42% (95% CI 24–58) and 27% (95% CI 12–44), respectively, compared with 20% (95% CI 15–26) and 11% (95% CI 7–16) for early DM (p = 0.01; Fig. 1c).

The late DM were located in the lungs in 14 cases, multiple sites in 6 cases, and lymph nodes in 5 cases. The remaining 7 cases were DM to soft tissue or bone. Nineteen patients had surgery for DM.

Discussion

The clinical importance of established risk factors to provide prognostic information regarding late recurrences is unclear, and somewhat contradictory results have been provided in previous studies.18–21 We have analyzed a population-based series of soft tissue sarcomas to evaluate if it is possible to identify patients with an increased risk of late recurrence.

Late recurrence in the literature are often defined as a recurrence diagnosed later than 5 years after the primary diagnosis and treatment.19,20,22 We have chosen 3 years, because we believe it better reflects the recurrence pattern of STS. After 3 years, the incidence of recurrences even out and the hazard rate stays consistent for the years following thereafter (Table 1; Fig. 1a). Moreover, guidelines recommend longer surveillance interval for high-grade tumors to twice a year after 2–3 years, at which time approximately 80% of recurrences have been identified.3,5,10,14,15,31

We found, as expected, that surgical margin correlated with risk of developing late LR. Using R0 wide margin as reference, both R0 marginal and R1 margins were factors that indicated increased risk for late LR. The observed univariable statistical correlation between radiotherapy and increased frequency of late LR, however, is interpreted as being caused by confounding factors, because patients who received radiotherapy, in general, were selected due to inadequate surgical margins and high-risk tumor characteristics.

Surgical margin also correlated with increased risk for late DM, although the global significance test was nonsignificant. An R0 marginal surgical margin correlated with increased risk for late DM, and there was a trend for a correlation of R1, although not statistically significant. The latter is probably explained by a type II error as a result of a small sample size. Tumor size ≥5 cm and vascular invasion had a statistically significant correlation with late DM in univariable analysis but could not be shown to be independent risk factors when performing multivariable analysis. The only risk factor for late DM that remained statistically significant in multivariable analysis was high malignancy grade.

It has been suggested that low-grade tumors may be prone to recur late, but this is not in line with the results in this study.5,32 Of 100 patients with low-grade tumor, LR occurred in 17 cases of which 5 were late. The primary tumor was excised with R0 wide surgical margin in 3 of these 17 cases. Eight of 100 patients with low-grade tumors developed DM, of whom 6 presented early and 2 presented late. None of these tumors were operated with R0 wide margin, suggesting that patients with low-grade STS treated with R0 wide margin run a low risk for both LR and DM.

Although treatment of recurrent sarcoma may be challenging, we found that the 3- and 5-year OS from diagnosis and treatment of a late LR were comparable to the 3- and 5-year OS for patients after primary diagnosis and treatment of STS.33,34 Moreover, outcome for patients treated for late recurrences, both LR and DM, was better than for patients treated for early recurrences.

In this study, approximately one-third of late DM were preceded by a late LR. It has been discussed whether the increased incidence of DM following LR is subsequent to the LR itself, but this is now more considered a manifestation of an aggressive tumor biology.7,21,35

Recurrence following a long period of remission after treatment constitutes a clinical problem in various malignancies.36 The causing mechanisms are poorly understood, but it is suggested that late recurrence involves multiple mechanisms of tumor dormancy, such as immunosurveillance, angiogenic dormancy, and cellular dormancy (G0–G1 arrest) by disrupted signaling pathways in the microenvironment.36,37 In this series, STS patients with late events, both LR and DM, had better post-recurrence survival compared with those with early recurrence (Fig. 1b, c) irrespective of tumor histotype. This suggests unknown biological differences between tumors in early and late STS recurrences.

In the literature, reports of surgical margins differ and various margin classification systems are used.38 It has been shown that a system that distinguishes marginal margin from wide margin provides more prognostic information than a dichotomous system that only reports negative versus positive margin.39–41 It has been argued that a marginal margin behaves closer to a positive margin than a negative margin.39 We found that R0 marginal margin is correlated with increased frequency of late events compared R0 wide margin, both classified as negative margin.

Early detection of LR and DM may increase chances to offer effective treatment and improve the chance of long-term survival. Studies have shown that approximately one-half of LR are detected by the patient in-between clinical visits, which is in line with our findings.15,42–44 In our series, late LR were identified by the patient in 17 of the 27 cases with available data. In a study by Nakamura et al., approximately one-half of all recurrences (either LR or DM) diagnosed later than 5 years from the initial treatment were detected at follow-up and the other half due to clinical symptoms.19 Hence, patient information and awareness of self-examination is an important strategy to improve surveillance as a complement to the routine follow-up.

We were not able to define any specific characteristics of patients or tumors that predict a high risk of late recurrence. Risk factors for late recurrence appear to be the same as for early (supplementary tables), but many risk factors predicting early recurrence did not predict late recurrence. Nonwide surgical margin was associated with increased risk for late recurrence, both LR and DM. We, therefore, emphasize the importance of regular and long-term surveillance for these patients. After treatment of a late LR, it is reasonable to schedule an adequate follow-up strategy, because about one-third of the patients were later diagnosed with DM. High-grade tumors, especially when excised with close margin, should be followed for a long period of time as the risk of late recurrence was not negligible, and the outcome after treatment in this series was good.

This study was performed using data collected prospectively to the national sarcoma quality register during a long period of time. The rarity of late events result in a limited number of cases. This reduces the possibilities to draw strong conclusions and identify clear patterns for risk factors predicting prognosis and outcome. Comparison of results also are made more complicated by international and historical differences in grading systems and resection margins for STS. However, this study is based on a population based series of STS, with long median follow-up and therefore may be considered to reveal a good reflection of incidence and outcome for patients with late recurrence.

In summary, the study confirms that late recurrences of soft tissue sarcoma are relatively rare. Nevertheless, late recurrences do occur and are often successfully treated. Approximately one-third of late DM were preceded by a late LR. Hence, patients should be followed frequently after treatment of a late LR. The better survival after late recurrence might be explained by differences in tumor biology, indicating that early events reflect a more aggressive tumor, even if representing the same histopathologic entity. This calls for an active surveillance strategy of all STS patients with high-grade tumors, because long-term survival indeed is possible to achieve even after a late recurrence.

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 152 KB)