| Literature DB >> 33860897 |
Osmar Vieira Ramires Júnior1, Barbara da Silva Alves1, Paula Alice Bezerra Barros2, Jamile Lima Rodrigues2, Shana Pires Ferreira1, Linda Karolynne Seregni Monteiro2, Gabriela de Moraes Soares Araújo1, Sara Silva Fernandes1, Gustavo Richter Vaz1, Cristiana Lima Dora1,2, Mariana Appel Hort3,4.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. Recent studies have shown that curcumin (CUR) has neuroprotective effects in PD experimental models. However, its efficacy is limited due to low water solubility, bioavailability, and access to the central nervous system. In this study, we compared the effects of new curcumin-loaded nanoemulsions (NC) and free CUR in an experimental model of PD. Adult Swiss mice received NC or CUR (25 and 50 mg/kg) or vehicle orally for 30 days. Starting on the eighth day, they were administered rotenone (1 mg/kg) intraperitoneally until the 30th day. At the end of the treatment, motor assessment was evaluated by open field, pole test, and beam walking tests. Oxidative stress markers and mitochondrial complex I activity were measured in the brain tissue. Both NC and CUR treatment significantly improved motor impairment, reduced lipoperoxidation, modified antioxidant defenses, and prevented inhibition of complex I. However, NC was more effective in preventing motor impairment and inhibition of complex I when compared to CUR in the free form. In conclusion, our results suggest that NC effectively enhances the neuroprotective potential of CUR and is a promising nanomedical application for PD.Entities:
Keywords: Curcumin; Motor impairment; Nanoparticles; Oxidative stress; Parkinson’s disease
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Year: 2021 PMID： 33860897 DOI： 10.1007/s12640-021-00362-w
Source DB: PubMed Journal: Neurotox Res ISSN： 1029-8428 Impact factor: 3.978