Danielle Wendel1, Conrad R Cole2, Valeria C Cohran3. 1. Division of Gastroenterology and Hepatology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA. danielle.wendel@seattlechildrens.org. 2. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USA. 3. Division of Gastroenterology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Abstract
PURPOSE OF REVIEW: Pediatric intestinal failure is a complex condition requiring specialized care to prevent potential complications. In this article, we review the available evidence supporting recent advances in care for children with intestinal failure. RECENT FINDINGS: Multidisciplinary intestinal rehabilitation teams utilize medical and surgical management techniques to help patients achieve enteral autonomy (EA) while preventing and treating the complications associated with intestinal failure. Recent advances in lipid management strategies, minimization of intestinal failure associated liver disease, prevention of central line-associated blood stream infections, and loss of access, as well as development of promising new hormone analogue therapy have allowed promotion of intestinal adaptation. These advances have decreased the need for intestinal transplant. There have been recent advances in the care of children with intestinal failure decreasing morbidity, mortality, and need for intestinal transplantation. The most promising new therapies involve replacement of enteroendocrine hormones.
PURPOSE OF REVIEW: Pediatric intestinal failure is a complex condition requiring specialized care to prevent potential complications. In this article, we review the available evidence supporting recent advances in care for children with intestinal failure. RECENT FINDINGS: Multidisciplinary intestinal rehabilitation teams utilize medical and surgical management techniques to help patients achieve enteral autonomy (EA) while preventing and treating the complications associated with intestinal failure. Recent advances in lipid management strategies, minimization of intestinal failure associated liver disease, prevention of central line-associated blood stream infections, and loss of access, as well as development of promising new hormone analogue therapy have allowed promotion of intestinal adaptation. These advances have decreased the need for intestinal transplant. There have been recent advances in the care of children with intestinal failure decreasing morbidity, mortality, and need for intestinal transplantation. The most promising new therapies involve replacement of enteroendocrine hormones.
Authors: Yaron Avitzur; Jenny Y Wang; Nicole T de Silva; Karolina M Burghardt; Maria DeAngelis; David Grant; Vicky L Ng; Nicola Jones; Paul W Wales Journal: J Pediatr Gastroenterol Nutr Date: 2015-07 Impact factor: 2.839
Authors: Carol Oliveira; Nicole T de Silva; Sanja Stanojevic; Yaron Avitzur; Ahmed M Bayoumi; Wendy J Ungar; Jeffrey S Hoch; Paul W Wales Journal: J Am Coll Surg Date: 2016-03-18 Impact factor: 6.113
Authors: O J Goulet; Y Revillon; D Jan; S De Potter; C Maurage; S Lortat-Jacob; H Martelli; C Nihoul-Fekete; C Ricour Journal: J Pediatr Date: 1991-07 Impact factor: 4.406
Authors: Brenna S Fullerton; Eric A Sparks; Amber M Hall; Christopher Duggan; Tom Jaksic; Biren P Modi Journal: J Pediatr Surg Date: 2015-10-23 Impact factor: 2.545
Authors: Robert H Squires; Christopher Duggan; Daniel H Teitelbaum; Paul W Wales; Jane Balint; Robert Venick; Susan Rhee; Debra Sudan; David Mercer; J Andres Martinez; Beth A Carter; Jason Soden; Simon Horslen; Jeffrey A Rudolph; Samuel Kocoshis; Riccardo Superina; Sharon Lawlor; Tamara Haller; Marcia Kurs-Lasky; Steven H Belle Journal: J Pediatr Date: 2012-05-11 Impact factor: 4.406