Literature DB >> 33860088

Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

Naoyuki Iwahashi1, Midori Ikezaki2, Hiroyuki Saito3, Kenji Uchimura4, Kazuchika Nishitsuji2.   

Abstract

The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of heparan sulfate (heparan sulfate S-domains), participate in cancer pathology by mediating transcellular propagation of p53 aggregates.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  glycosaminoglycan; heparan sulfate; p53; prion; protein aggregates

Year:  2021        PMID： 33860088      PMCID： PMC8018399          DOI： 10.1080/23723556.2021.1892444

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Sulfated glycosaminoglycans in protein aggregation diseases.

Authors:  Kazuchika Nishitsuji; Kenji Uchimura
Journal:  Glycoconj J       Date:  2017-04-11       Impact factor: 2.916

2.  Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients.

Authors:  Tomomi Hosono-Fukao; Shiori Ohtake-Niimi; Hitomi Hoshino; Markus Britschgi; Hiroyasu Akatsu; Md Motarab Hossain; Kazuchika Nishitsuji; Toin H van Kuppevelt; Koji Kimata; Makoto Michikawa; Tony Wyss-Coray; Kenji Uchimura
Journal:  Am J Pathol       Date:  2012-03-17       Impact factor: 4.307

3.  Cellular interaction and cytotoxicity of the iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate.

Authors:  Kaori Kuwabara; Kazuchika Nishitsuji; Kenji Uchimura; Shang-Cheng Hung; Makoto Mizuguchi; Hiroyuki Nakajima; Shiho Mikawa; Norihiro Kobayashi; Hiroyuki Saito; Naomi Sakashita
Journal:  J Biol Chem       Date:  2015-08-19       Impact factor: 5.157

4.  Unconventional Secretion Mediates the Trans-cellular Spreading of Tau.

Authors:  Taxiarchis Katsinelos; Marcel Zeitler; Eleni Dimou; Andromachi Karakatsani; Hans-Michael Müller; Eliana Nachman; Julia P Steringer; Carmen Ruiz de Almodovar; Walter Nickel; Thomas R Jahn
Journal:  Cell Rep       Date:  2018-05-15       Impact factor: 9.423

5.  The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity.

Authors:  Hirokazu Kameyama; Kenji Uchimura; Taro Yamashita; Kaori Kuwabara; Mineyuki Mizuguchi; Shang-Cheng Hung; Keiichiro Okuhira; Tomohiro Masuda; Tomoki Kosugi; Takashi Ohgita; Hiroyuki Saito; Yukio Ando; Kazuchika Nishitsuji
Journal:  Am J Pathol       Date:  2018-11-07       Impact factor: 4.307

6.  Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates.

Authors:  Naoyuki Iwahashi; Midori Ikezaki; Taro Nishikawa; Norihiro Namba; Takashi Ohgita; Hiroyuki Saito; Yoshito Ihara; Toshinori Shimanouchi; Kazuhiko Ino; Kenji Uchimura; Kazuchika Nishitsuji
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-14       Impact factor: 11.205

Review 7.  Prion-like aggregation of mutant p53 in cancer.

Authors:  Jerson L Silva; Claudia V De Moura Gallo; Danielly C F Costa; Luciana P Rangel
Journal:  Trends Biochem Sci       Date:  2014-04-26       Impact factor: 13.807

Review 8.  Heparan sulfate S-domains and extracellular sulfatases (Sulfs): their possible roles in protein aggregation diseases.

Authors:  Kazuchika Nishitsuji
Journal:  Glycoconj J       Date:  2018-07-12       Impact factor: 2.916

9.  Enzymatic remodeling of heparan sulfate: a therapeutic strategy for systemic and localized amyloidoses?

Authors:  Kazuchika Nishitsuji; Hiroyuki Saito; Kenji Uchimura
Journal:  Neural Regen Res       Date:  2016-03       Impact factor: 5.135

10.  Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.

Authors:  Merrill D Benson; Joel N Buxbaum; David S Eisenberg; Giampaolo Merlini; Maria J M Saraiva; Yoshiki Sekijima; Jean D Sipe; Per Westermark
Journal:  Amyloid       Date:  2020-10-26       Impact factor: 7.141
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.