Literature DB >> 33860085

It takes three to the DNA damage response tango.

Sapir Schlam-Babayov1, Yael Ziv1, Yosef Shiloh1.   

Abstract

The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  ATM; Ataxia-telangiectasia; DNA damage response; PIKKs; phosphoproteomic

Year:  2021        PMID： 33860085      PMCID： PMC8018445          DOI： 10.1080/23723556.2021.1881395

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Authors:  Andrew N Blackford; Stephen P Jackson
Journal:  Mol Cell       Date:  2017-06-15       Impact factor: 17.970

Review 2.  Chromosome instability syndromes.

Authors:  A Malcolm R Taylor; Cynthia Rothblum-Oviatt; Nathan A Ellis; Ian D Hickson; Stefan Meyer; Thomas O Crawford; Agata Smogorzewska; Barbara Pietrucha; Corry Weemaes; Grant S Stewart
Journal:  Nat Rev Dis Primers       Date:  2019-09-19       Impact factor: 52.329

Review 3.  The DNA damage response: implications for tumor responses to radiation and chemotherapy.

Authors:  Michael Goldstein; Michael B Kastan
Journal:  Annu Rev Med       Date:  2014-11-24       Impact factor: 13.739

Review 4.  Targeting DNA-PK in cancer.

Authors:  Giovanna Damia
Journal:  Mutat Res       Date:  2020-02-25       Impact factor: 2.433

5.  Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

Authors:  Yi Zhou; Ji-Hoon Lee; Wenxia Jiang; Jennie L Crowe; Shan Zha; Tanya T Paull
Journal:  Mol Cell       Date:  2016-12-08       Impact factor: 17.970

6.  Phosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress.

Authors:  Sapir Schlam-Babayov; Ariel Bensimon; Michal Harel; Tamar Geiger; Ruedi Aebersold; Yael Ziv; Yosef Shiloh
Journal:  EMBO J       Date:  2020-11-20       Impact factor: 11.598

Review 7.  ATM and ATR as therapeutic targets in cancer.

Authors:  Anika Maria Weber; Anderson Joseph Ryan
Journal:  Pharmacol Ther       Date:  2014-12-13       Impact factor: 12.310

8.  Loss of ATM kinase activity leads to embryonic lethality in mice.

Authors:  Jeremy A Daniel; Manuela Pellegrini; Baeck-Seung Lee; Zhi Guo; Darius Filsuf; Natalya V Belkina; Zhongsheng You; Tanya T Paull; Barry P Sleckman; Lionel Feigenbaum; André Nussenzweig
Journal:  J Cell Biol       Date:  2012-08-06       Impact factor: 10.539

9.  Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.

Authors:  Kenta Yamamoto; Yunyue Wang; Wenxia Jiang; Xiangyu Liu; Richard L Dubois; Chyuan-Sheng Lin; Thomas Ludwig; Christopher J Bakkenist; Shan Zha
Journal:  J Cell Biol       Date:  2012-08-06       Impact factor: 10.539

10.  Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.

Authors:  Ana Finzel; Andrea Grybowski; Jette Strasen; Elena Cristiano; Alexander Loewer
Journal:  Mol Biol Cell       Date:  2016-06-08       Impact factor: 4.138
  10 in total

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