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Literature DB >> 33860084

Trex2 responds to damaged replication forks in diverse ways.

Abstract

Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with different HR-defects. Why does Trex2 have such diverse effects on RF maintenance?

Entities: Chemical

Year: 2021 PMID： 33860084 PMCID： PMC8018345 DOI： 10.1080/23723556.2021.1881394

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. RAD51 mutants cause replication defects and chromosomal instability.

Authors: Tae Moon Kim; Jun Ho Ko; Lingchuan Hu; Sung-A Kim; Alexander J R Bishop; Jan Vijg; Cristina Montagna; Paul Hasty
Journal: Mol Cell Biol Date: 2012-07-09 Impact factor: 4.272

2. The phenotype of FancB-mutant mouse embryonic stem cells.

Authors: Tae Moon Kim; Jun Ho Ko; Yong Jun Choi; Lingchuan Hu; Paul Hasty
Journal: Mutat Res Date: 2011-03-30 Impact factor: 2.433

3. Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes.

Authors: Lingchuan Hu; Tae Moon Kim; Mi Young Son; Sung-A Kim; Cory L Holland; Satoshi Tateishi; Dong Hyun Kim; P Renee Yew; Cristina Montagna; Lavinia C Dumitrache; Paul Hasty
Journal: Nature Date: 2013-09-08 Impact factor: 49.962

4. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Authors: Arun Mouli Kolinjivadi; Vincenzo Sannino; Anna De Antoni; Karina Zadorozhny; Mairi Kilkenny; Hervé Técher; Giorgio Baldi; Rong Shen; Alberto Ciccia; Luca Pellegrini; Lumir Krejci; Vincenzo Costanzo
Journal: Mol Cell Date: 2017-07-27 Impact factor: 17.970

5. Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.

Authors: Min Peng; Ke Cong; Nicholas J Panzarino; Sumeet Nayak; Jennifer Calvo; Bin Deng; Lihua Julie Zhu; Monika Morocz; Lili Hegedus; Lajos Haracska; Sharon B Cantor
Journal: Cell Rep Date: 2018-09-18 Impact factor: 9.423

6. TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51^K133A.

Authors: Jun Ho Ko; Mi Young Son; Qing Zhou; Lucia Molnarova; Lambert Song; Jarmila Mlcouskova; Atis Jekabsons; Cristina Montagna; Lumir Krejci; Paul Hasty
Journal: Cell Rep Date: 2020-12-22 Impact factor: 9.423

7. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

Authors: Angelo Taglialatela; Silvia Alvarez; Giuseppe Leuzzi; Vincenzo Sannino; Lepakshi Ranjha; Jen-Wei Huang; Chioma Madubata; Roopesh Anand; Brynn Levy; Raul Rabadan; Petr Cejka; Vincenzo Costanzo; Alberto Ciccia
Journal: Mol Cell Date: 2017-10-19 Impact factor: 17.970

8. Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.

Authors: Ming-Jiu Chen; Sheng-Mei Ma; Lavinia C Dumitrache; Paul Hasty
Journal: Nucleic Acids Res Date: 2007-04-10 Impact factor: 16.971

9. Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.

Authors: Matteo Berti; Arnab Ray Chaudhuri; Saravanabhavan Thangavel; Shivasankari Gomathinayagam; Sasa Kenig; Marko Vujanovic; Federico Odreman; Timo Glatter; Simona Graziano; Ramiro Mendoza-Maldonado; Francesca Marino; Bojana Lucic; Valentina Biasin; Matthias Gstaiger; Ruedi Aebersold; Julia M Sidorova; Raymond J Monnat; Massimo Lopes; Alessandro Vindigni
Journal: Nat Struct Mol Biol Date: 2013-02-10 Impact factor: 15.369

10. Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.

Authors: Marko Vujanovic; Jana Krietsch; Maria Chiara Raso; Nastassja Terraneo; Ralph Zellweger; Jonas A Schmid; Angelo Taglialatela; Jen-Wei Huang; Cory L Holland; Katharina Zwicky; Raquel Herrador; Heinz Jacobs; David Cortez; Alberto Ciccia; Lorenza Penengo; Massimo Lopes
Journal: Mol Cell Date: 2017-09-07 Impact factor: 17.970

10 in total

1 in total

1. Functional Validation of cas9/guideRNA Constructs for Site-Directed Mutagenesis of Triticale ABA8'OH1 loci.

Authors: Krzysztof Michalski; Christian Hertig; Dariusz R Mańkowski; Jochen Kumlehn; Janusz Zimny; Anna M Linkiewicz
Journal: Int J Mol Sci Date: 2021-06-29 Impact factor: 5.923

1 in total