Literature DB >> 33860083

The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis.

Youwei Ai1,2, Bo Yan1, Xiaodong Wang1,2.   

Abstract

Our recent study showed that two oxidoreductases - NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) - transfer electrons to oxygen to generate hydrogen peroxide (H2O2). H2O2 then reacts with ferrous iron, generating hydroxyl radicals that cause peroxidation of polyunsaturated-fatty-acid chains of membrane phospholipids, resulting in plasma membrane rupture and ferroptosis.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  CYB5R1; FSP1; Ferroptosis; GPX4; H2O2; POR; PUFA; hydroxyl radicals; lipid peroxidation; oxidoreductase

Year:  2021        PMID： 33860083      PMCID： PMC8018466          DOI： 10.1080/23723556.2021.1881393

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  FSP1 is a glutathione-independent ferroptosis suppressor.

Authors:  Sebastian Doll; Florencio Porto Freitas; Ron Shah; Maceler Aldrovandi; Milene Costa da Silva; Irina Ingold; Andrea Goya Grocin; Thamara Nishida Xavier da Silva; Elena Panzilius; Christina H Scheel; André Mourão; Katalin Buday; Mami Sato; Jonas Wanninger; Thibaut Vignane; Vaishnavi Mohana; Markus Rehberg; Andrew Flatley; Aloys Schepers; Andreas Kurz; Daniel White; Markus Sauer; Michael Sattler; Edward William Tate; Werner Schmitz; Almut Schulze; Valerie O'Donnell; Bettina Proneth; Grzegorz M Popowicz; Derek A Pratt; José Pedro Friedmann Angeli; Marcus Conrad
Journal:  Nature       Date:  2019-10-21       Impact factor: 49.962

2.  Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.

Authors:  Bo Yan; Youwei Ai; Qi Sun; Yan Ma; Yang Cao; Jiawen Wang; Zhiyuan Zhang; Xiaodong Wang
Journal:  Mol Cell       Date:  2020-12-14       Impact factor: 17.970

3.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

Authors:  Jianjin Shi; Yue Zhao; Kun Wang; Xuyan Shi; Yue Wang; Huanwei Huang; Yinghua Zhuang; Tao Cai; Fengchao Wang; Feng Shao
Journal:  Nature       Date:  2015-09-16       Impact factor: 49.962

4.  Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Authors:  Scott J Dixon; Kathryn M Lemberg; Michael R Lamprecht; Rachid Skouta; Eleina M Zaitsev; Caroline E Gleason; Darpan N Patel; Andras J Bauer; Alexandra M Cantley; Wan Seok Yang; Barclay Morrison; Brent R Stockwell
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

5.  Regulation of ferroptotic cancer cell death by GPX4.

Authors:  Wan Seok Yang; Rohitha SriRamaratnam; Matthew E Welsch; Kenichi Shimada; Rachid Skouta; Vasanthi S Viswanathan; Jaime H Cheah; Paul A Clemons; Alykhan F Shamji; Clary B Clish; Lewis M Brown; Albert W Girotti; Virginia W Cornish; Stuart L Schreiber; Brent R Stockwell
Journal:  Cell       Date:  2014-01-16       Impact factor: 41.582

6.  Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.

Authors:  Yilong Zou; Haoxin Li; Emily T Graham; Amy A Deik; John K Eaton; Wenyu Wang; Gerardo Sandoval-Gomez; Clary B Clish; John G Doench; Stuart L Schreiber
Journal:  Nat Chem Biol       Date:  2020-02-17       Impact factor: 15.040

7.  Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

Authors:  Huayi Wang; Liming Sun; Lijing Su; Josep Rizo; Lei Liu; Li-Feng Wang; Fu-Sheng Wang; Xiaodong Wang
Journal:  Mol Cell       Date:  2014-04-03       Impact factor: 17.970

8.  The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

Authors:  Kirill Bersuker; Joseph M Hendricks; Zhipeng Li; Leslie Magtanong; Breanna Ford; Peter H Tang; Melissa A Roberts; Bingqi Tong; Thomas J Maimone; Roberto Zoncu; Michael C Bassik; Daniel K Nomura; Scott J Dixon; James A Olzmann
Journal:  Nature       Date:  2019-10-21       Impact factor: 49.962
  8 in total
  2 in total

Review 1.  Relevance of Ferroptosis to Cardiotoxicity Caused by Anthracyclines: Mechanisms to Target Treatments.

Authors:  Guoxia Zhang; Chao Yuan; Xin Su; Jianzhen Zhang; Priyanka Gokulnath; Gururaja Vulugundam; Guoping Li; Xinyu Yang; Na An; Can Liu; Wanli Sun; Hengwen Chen; Min Wu; Shipeng Sun; Yanwei Xing
Journal:  Front Cardiovasc Med       Date:  2022-06-13

Review 2.  Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants.

Authors:  Charareh Pourzand; Andrea Albieri-Borges; Nico N Raczek
Journal:  Antioxidants (Basel)       Date:  2022-02-27
  2 in total

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