Literature DB >> 33860082

An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint.

Eleni Petsalaki1, George Zachos1.   

Abstract

In response to chromatin bridges, the chromosomal passenger complex (CPC) delays completion of cytokinesis (abscission) to prevent chromosome breakage. Here, we discuss recent findings from our lab showing that an ATM-CHK2-INCENP pathway imposes the abscission checkpoint in human cells by regulating CPC midbody-localization.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  ATM; CHK2; CPC; Chromatin bridges; INCENP; MRN; abscission checkpoint; cytokinesis; midbody

Year:  2021        PMID： 33860082      PMCID： PMC8018396          DOI： 10.1080/23723556.2021.1877999

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis.

Authors:  Mayumi Kitagawa; Suet Yin Sarah Fung; Umar Farook Shahul Hameed; Hidemasa Goto; Masaki Inagaki; Sang Hyun Lee
Journal:  Cell Rep       Date:  2014-03-20       Impact factor: 9.423

Review 2.  Building bridges between chromosomes: novel insights into the abscission checkpoint.

Authors:  Eleni Petsalaki; George Zachos
Journal:  Cell Mol Life Sci       Date:  2019-07-13       Impact factor: 9.261

3.  MKLP2 Is a Motile Kinesin that Transports the Chromosomal Passenger Complex during Anaphase.

Authors:  Ingrid E Adriaans; Peter Jan Hooikaas; Amol Aher; Martijn J M Vromans; Robert M van Es; Ilya Grigoriev; Anna Akhmanova; Susanne M A Lens
Journal:  Curr Biol       Date:  2020-06-04       Impact factor: 10.834

Review 4.  Cytokinesis defects and cancer.

Authors:  Susanne M A Lens; René H Medema
Journal:  Nat Rev Cancer       Date:  2019-01       Impact factor: 60.716

5.  Aurora B-mediated abscission checkpoint protects against tetraploidization.

Authors:  Patrick Steigemann; Claudia Wurzenberger; Michael H A Schmitz; Michael Held; Julien Guizetti; Sandra Maar; Daniel W Gerlich
Journal:  Cell       Date:  2009-02-06       Impact factor: 41.582

Review 6.  The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.

Authors:  Mar Carmena; Michael Wheelock; Hironori Funabiki; William C Earnshaw
Journal:  Nat Rev Mol Cell Biol       Date:  2012-12       Impact factor: 94.444

7.  ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C.

Authors:  Jeremy G Carlton; Anna Caballe; Monica Agromayor; Magdalena Kloc; Juan Martin-Serrano
Journal:  Science       Date:  2012-03-15       Impact factor: 47.728

8.  An ATM-Chk2-INCENP pathway activates the abscission checkpoint.

Authors:  Eleni Petsalaki; George Zachos
Journal:  J Cell Biol       Date:  2021-02-01       Impact factor: 10.539

9.  Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.

Authors:  Eleni Petsalaki; George Zachos
Journal:  Nat Commun       Date:  2016-04-29       Impact factor: 14.919

10.  Mechanisms generating cancer genome complexity from a single cell division error.

Authors:  Neil T Umbreit; Cheng-Zhong Zhang; Luke D Lynch; Logan J Blaine; Anna M Cheng; Richard Tourdot; Lili Sun; Hannah F Almubarak; Kim Judge; Thomas J Mitchell; Alexander Spektor; David Pellman
Journal:  Science       Date:  2020-04-17       Impact factor: 47.728
  10 in total

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