Literature DB >> 33860080

P53 regulates cellular redox state, ferroptosis and metabolism.

Julia I-Ju Leu1, Maureen E Murphy2, Donna L George1.   

Abstract

The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Ferroptosis; cysteine modification; metabolism; p53; redox signaling

Year:  2021        PMID： 33860080      PMCID： PMC8018455          DOI： 10.1080/23723556.2021.1877076

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease.

Authors:  Juan I Sbodio; Solomon H Snyder; Bindu D Paul
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-19       Impact factor: 11.205

Review 2.  Blinded by the Light: The Growing Complexity of p53.

Authors:  Karen H Vousden; Carol Prives
Journal:  Cell       Date:  2009-05-01       Impact factor: 41.582

Review 3.  The cysteine proteome.

Authors:  Young-Mi Go; Joshua D Chandler; Dean P Jones
Journal:  Free Radic Biol Med       Date:  2015-04-03       Impact factor: 7.376

4.  Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

Authors:  Julia I-Ju Leu; Maureen E Murphy; Donna L George
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-08       Impact factor: 11.205

5.  Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.

Authors:  Junmei Yi; Jiajun Zhu; Jiao Wu; Craig B Thompson; Xuejun Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-23       Impact factor: 11.205

6.  Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

Authors:  Julia I-Ju Leu; Maureen E Murphy; Donna L George
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-14       Impact factor: 11.205

Review 7.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Authors:  Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang
Journal:  Cell       Date:  2017-10-05       Impact factor: 41.582

8.  Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.

Authors:  Scott J Dixon; Darpan N Patel; Matthew Welsch; Rachid Skouta; Eric D Lee; Miki Hayano; Ajit G Thomas; Caroline E Gleason; Nicholas P Tatonetti; Barbara S Slusher; Brent R Stockwell
Journal:  Elife       Date:  2014-05-20       Impact factor: 8.140

9.  A functionally significant SNP in TP53 and breast cancer risk in African-American women.

Authors:  Maureen E Murphy; Song Liu; Song Yao; Dezheng Huo; Qin Liu; Sonia C Dolfi; Kim M Hirshfield; Chi-Chen Hong; Qiang Hu; Andrew F Olshan; Temidayo O Ogundiran; Clement Adebamowo; Susan M Domchek; Katherine L Nathanson; Barbara Nemesure; Stefan Ambs; William J Blot; Ye Feng; Esther M John; Leslie Bernstein; Wei Zheng; Jennifer J Hu; Regina G Ziegler; Sarah Nyante; Sue A Ingles; Michael F Press; Sandra L Deming; Jorge L Rodriguez-Gil; Christopher A Haiman; Olufunmilayo I Olopade; Kathryn L Lunetta; Julie R Palmer; Christine B Ambrosone
Journal:  NPJ Breast Cancer       Date:  2017-02-27

10.  Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.

Authors:  Keerthana Gnanapradeepan; Julia I-Ju Leu; Subhasree Basu; Thibaut Barnoud; Madeline Good; Joyce V Lee; William J Quinn; Che-Pei Kung; Rexford Ahima; Joseph A Baur; Kathryn E Wellen; Qin Liu; Zachary T Schug; Donna L George; Maureen E Murphy
Journal:  Elife       Date:  2020-11-10       Impact factor: 8.140
  10 in total
  1 in total

1.  p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer.

Authors:  Alessio Butera; Micaela Roy; Carlotta Zampieri; Eleonora Mammarella; Emanuele Panatta; Gerry Melino; Angelo D'Alessandro; Ivano Amelio
Journal:  Biol Direct       Date:  2022-03-08       Impact factor: 4.540
  1 in total

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