Literature DB >> 33860078

Age-induced metabolic reprogramming underlies cancer progression.

Didem Ilter1, Ana P Gomes1.   

Abstract

Aging is a main risk factor for cancer. Using human serum we demonstrated that tumor progression and metastases occur, at least in part, as a manifestation of global metabolic deregulation of the aged host. This shows that the role of aging in cancer goes far beyond increased exposure time to mutagens; the aging process coordinates various aspects required for malignancy.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Aging; metabolism; metastasis

Year:  2021        PMID： 33860078      PMCID： PMC8018342          DOI： 10.1080/23723556.2021.1876506

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Journal:  CA Cancer J Clin       Date:  2020-01-08       Impact factor: 508.702

2.  Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline.

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Journal:  Neurology       Date:  2009-01-27       Impact factor: 9.910

3.  Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.

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Journal:  Cancer Discov       Date:  2018-10-02       Impact factor: 39.397

Review 4.  Normal Aging and Its Role in Cancer Metastasis.

Authors:  Mitchell Fane; Ashani T Weeraratna
Journal:  Cold Spring Harb Perspect Med       Date:  2020-09-01       Impact factor: 5.159

5.  Ovarian cancer in younger vs older women: a population-based analysis.

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6.  Age is associated with prognosis in serous ovarian carcinoma.

Authors:  Fei Deng; Xia Xu; Mengmeng Lv; Binhui Ren; Yan Wang; Wenwen Guo; Jifeng Feng; Xiaoxiang Chen
Journal:  J Ovarian Res       Date:  2017-06-12       Impact factor: 4.234

Review 7.  Paracrine roles of cellular senescence in promoting tumourigenesis.

Authors:  Jose Mario Gonzalez-Meljem; John Richard Apps; Helen Christina Fraser; Juan Pedro Martinez-Barbera
Journal:  Br J Cancer       Date:  2018-04-19       Impact factor: 7.640

8.  Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population.

Authors:  Shanjie Wang; Yige Liu; Jinxin Liu; Wei Tian; Xiaoyuan Zhang; Hengxuan Cai; Shaohong Fang; Bo Yu
Journal:  Redox Biol       Date:  2020-09-30       Impact factor: 11.799

9.  Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.

Authors:  Daryl J Wile; Cory Toth
Journal:  Diabetes Care       Date:  2009-10-21       Impact factor: 19.112

10.  Age-induced accumulation of methylmalonic acid promotes tumour progression.

Authors:  Ana P Gomes; Didem Ilter; Vivien Low; Jennifer E Endress; Juan Fernández-García; Adam Rosenzweig; Tanya Schild; Dorien Broekaert; Adnan Ahmed; Melanie Planque; Ilaria Elia; Julie Han; Charles Kinzig; Edouard Mullarky; Anders P Mutvei; John Asara; Rafael de Cabo; Lewis C Cantley; Noah Dephoure; Sarah-Maria Fendt; John Blenis
Journal:  Nature       Date:  2020-08-19       Impact factor: 49.962
  10 in total

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