Literature DB >> 33860077

Phosphoglycerate mutase 1 (PGAM1) overexpression promotes radio- and chemoresistance in gliomas by activating the DNA damage response.

Tor-Christian Aase Johannessen1,2, Joydeep Mukherjee2.   

Abstract

The glycolytic enzyme PGAM1 is overexpressed in gliomas where it efficiently facilitates the repair of DNA damage. Mechanistically, PGAM1 prevents inactivation of the ataxia-telangiectasia mutated (ATM) signaling pathway by sequestering the wild-type p53-induced phosphatase 1 (WIP1) in the cytoplasm. Genetic inhibition of PGAM1 expression subsequently sensitizes glioma cells against irradiation and chemotherapy-induced DNA damage.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  DNA damage repair; Glioma; IR; PGAM1; TMZ; WIP1; treatment resistance

Year:  2021        PMID： 33860077      PMCID： PMC8018509          DOI： 10.1080/23723556.2021.1875804

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.

Authors:  Tor-Christian Aase Johannessen; Rolf Bjerkvig
Journal:  Expert Rev Anticancer Ther       Date:  2012-05       Impact factor: 4.512

Review 2.  The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Authors:  David N Louis; Arie Perry; Guido Reifenberger; Andreas von Deimling; Dominique Figarella-Branger; Webster K Cavenee; Hiroko Ohgaki; Otmar D Wiestler; Paul Kleihues; David W Ellison
Journal:  Acta Neuropathol       Date:  2016-05-09       Impact factor: 17.088

3.  Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Authors:  Matthew G Vander Heiden; Jason W Locasale; Kenneth D Swanson; Hadar Sharfi; Greg J Heffron; Daniel Amador-Noguez; Heather R Christofk; Gerhard Wagner; Joshua D Rabinowitz; John M Asara; Lewis C Cantley
Journal:  Science       Date:  2010-09-17       Impact factor: 47.728

4.  Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity.

Authors:  D Zhang; N Jin; W Sun; X Li; B Liu; Z Xie; J Qu; J Xu; X Yang; Y Su; S Tang; H Han; D Chen; J Ding; M Tan; M Huang; M Geng
Journal:  Oncogene       Date:  2016-12-19       Impact factor: 9.867

5.  Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity.

Authors:  Shigeo Ohba; Tor-Christian Aase Johannessen; Kamalakar Chatla; Xiaodong Yang; Russell O Pieper; Joydeep Mukherjee
Journal:  Cell Rep       Date:  2020-04-14       Impact factor: 9.423

6.  Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.

Authors:  Taro Hitosugi; Lu Zhou; Shannon Elf; Jun Fan; Hee-Bum Kang; Jae Ho Seo; Changliang Shan; Qing Dai; Liang Zhang; Jianxin Xie; Ting-Lei Gu; Peng Jin; Masa Alečković; Gary LeRoy; Yibin Kang; Jessica A Sudderth; Ralph J DeBerardinis; Chi-Hao Luan; Georgia Z Chen; Susan Muller; Dong M Shin; Taofeek K Owonikoko; Sagar Lonial; Martha L Arellano; Hanna J Khoury; Fadlo R Khuri; Benjamin H Lee; Keqiang Ye; Titus J Boggon; Sumin Kang; Chuan He; Jing Chen
Journal:  Cancer Cell       Date:  2012-11-13       Impact factor: 31.743

7.  CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.

Authors:  Quinn T Ostrom; Gino Cioffi; Haley Gittleman; Nirav Patil; Kristin Waite; Carol Kruchko; Jill S Barnholtz-Sloan
Journal:  Neuro Oncol       Date:  2019-11-01       Impact factor: 12.300

8.  Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.

Authors:  Amparo Wolf; Sameer Agnihotri; Johann Micallef; Joydeep Mukherjee; Nesrin Sabha; Rob Cairns; Cynthia Hawkins; Abhijit Guha
Journal:  J Exp Med       Date:  2011-01-17       Impact factor: 14.307

9.  Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.

Authors:  Jia Qu; Wenyi Sun; Jie Zhong; Hao Lv; Mingrui Zhu; Jun Xu; Nan Jin; Zuoquan Xie; Minjia Tan; Shu-Hai Lin; Meiyu Geng; Jian Ding; Min Huang
Journal:  J Cell Biol       Date:  2017-01-25       Impact factor: 10.539

10.  Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.

Authors:  Joydeep Mukherjee; Joanna J Phillips; Shichun Zheng; John Wiencke; Sabrina M Ronen; Russell O Pieper
Journal:  PLoS One       Date:  2013-02-25       Impact factor: 3.240
  10 in total

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