Literature DB >> 33860076

Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking.

Maria F Czyzyk-Krzeska1,2, Jarek Meller3,4,5, Julio A Landero Figueroa6, David R Plas1, John T Cunningham1.   

Abstract

Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Clear cell renal cell carcinoma; arsenic; copper; oxidative phosphorylation; tobacco smoking

Year:  2021        PMID： 33860076      PMCID： PMC8018476          DOI： 10.1080/23723556.2020.1859917

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Authors:  Joshua D Ochocki; Sanika Khare; Markus Hess; Daniel Ackerman; Bo Qiu; Jennie I Daisak; Andrew J Worth; Nan Lin; Pearl Lee; Hong Xie; Bo Li; Bradley Wubbenhorst; Tobi G Maguire; Katherine L Nathanson; James C Alwine; Ian A Blair; Itzhak Nissim; Brian Keith; M Celeste Simon
Journal:  Cell Metab       Date:  2018-05-10       Impact factor: 27.287

2.  Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma.

Authors:  Francesco Gatto; Intawat Nookaew; Jens Nielsen
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

3.  In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.

Authors:  Paulo A Gameiro; Juanjuan Yang; Ana M Metelo; Rocio Pérez-Carro; Rania Baker; Zongwei Wang; Alexandra Arreola; W Kimryn Rathmell; Aria Olumi; Pilar López-Larrubia; Gregory Stephanopoulos; Othon Iliopoulos
Journal:  Cell Metab       Date:  2013-03-05       Impact factor: 27.287

4.  Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.

Authors:  Hai-Nan Zhang; Lina Yang; Jian-Ya Ling; Daniel M Czajkowsky; Jing-Fang Wang; Xiao-Wei Zhang; Yi-Ming Zhou; Feng Ge; Ming-Kun Yang; Qian Xiong; Shu-Juan Guo; Huang-Ying Le; Song-Fang Wu; Wei Yan; Bingya Liu; Heng Zhu; Zhu Chen; Sheng-Ce Tao
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-23       Impact factor: 11.205

Review 5.  HIF-1 mediates the Warburg effect in clear cell renal carcinoma.

Authors:  Gregg L Semenza
Journal:  J Bioenerg Biomembr       Date:  2007-06       Impact factor: 2.945

6.  Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.

Authors:  James Reigle; Dina Secic; Jacek Biesiada; Collin Wetzel; Behrouz Shamsaei; Johnson Chu; Yuanwei Zang; Xiang Zhang; Nicholas J Talbot; Megan E Bischoff; Yongzhen Zhang; Charuhas V Thakar; Krishnanath Gaitonde; Abhinav Sidana; Hai Bui; John T Cunningham; Qing Zhang; Laura S Schmidt; W Marston Linehan; Mario Medvedovic; David R Plas; Julio A Landero Figueroa; Jarek Meller; Maria F Czyzyk-Krzeska
Journal:  J Clin Invest       Date:  2021-01-04       Impact factor: 14.808

7.  Comprehensive molecular characterization of clear cell renal cell carcinoma.

Authors: 
Journal:  Nature       Date:  2013-06-23       Impact factor: 49.962

8.  Fructose-1,6-bisphosphatase opposes renal carcinoma progression.

Authors:  Bo Li; Bo Qiu; David S M Lee; Zandra E Walton; Joshua D Ochocki; Lijoy K Mathew; Anthony Mancuso; Terence P F Gade; Brian Keith; Itzhak Nissim; M Celeste Simon
Journal:  Nature       Date:  2014-07-20       Impact factor: 49.962
  8 in total

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