Literature DB >> 33855271

The future of genomics in Ireland - focus on genomics for health.

Cathal Seoighe1, Adrian P Bracken2, Patrick Buckley3, Peter Doran4,5, Robert Green6, Sandra Healy1, David Kavanagh3, Elaine Kenny2,7, Mark Lawler8, Maeve Lowery2,9, Derek Morris1, Darrin Morrissey10, James J O'Byrne5, Denis Shields4, Owen Smith4,11, Charles A Steward12, Brian Sweeney13, Walter Kolch1.   

Abstract

Genomics is revolutionizing biomedical research, medicine and healthcare globally in academic, public and industry sectors alike. Concrete examples around the world show that huge benefits for patients, society and economy can be accrued through effective and responsible genomic research and clinical applications. Unfortunately, Ireland has fallen behind and needs to act now in order to catch up. Here, we identify key issues that have resulted in Ireland lagging behind, describe how genomics can benefit Ireland and its people and outline the measures needed to make genomics work for Ireland and Irish patients. There is now an urgent need for a national genomics strategy that enables an effective, collaborative, responsible, well-regulated, and patient centred environment where genome research and clinical genomics can thrive.  We present eight recommendations that could be the pillars of a national genomics health strategy. Copyright:
© 2020 Seoighe C et al.

Entities:  

Keywords:  Genomics; ethics of genome research; genome research; health-economic assessment of clinical genomics; national genomics strategy; patient involvement; precision/personalized medicine; societal and economic aspects of genome research

Year:  2020        PMID: 33855271      PMCID: PMC7993626          DOI: 10.12688/hrbopenres.13187.1

Source DB:  PubMed          Journal:  HRB Open Res        ISSN: 2515-4826


  30 in total

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Authors:  Tapesh Santra; Ana Herrero; Javier Rodriguez; Alex von Kriegsheim; Luis F Iglesias-Martinez; Thomas Schwarzl; Des Higgins; Thin-Thin Aye; Albert J R Heck; Fernando Calvo; Lorena Agudo-Ibáñez; Piero Crespo; David Matallanas; Walter Kolch
Journal:  Cell Rep       Date:  2019-03-12       Impact factor: 9.423

Review 2.  The Value of Diagnostic Information in Personalised Healthcare: A Comprehensive Concept to Facilitate Bringing This Technology into Healthcare Systems.

Authors:  Victoria Wurcel; Americo Cicchetti; Louis Garrison; Michelle M A Kip; Hendrik Koffijberg; Anne Kolbe; Mariska M G Leeflang; Tracy Merlin; Jorge Mestre-Ferrandiz; Wija Oortwijn; Cor Oosterwijk; Sean Tunis; Bernarda Zamora
Journal:  Public Health Genomics       Date:  2019-07-22       Impact factor: 2.000

3.  Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions.

Authors:  Mark Lawler; David Haussler; Lillian L Siu; Melissa A Haendel; Julie A McMurry; Bartha M Knoppers; Stephen J Chanock; Fabien Calvo; Bin T The; Guneet Walia; Ian Banks; Peter P Yu; Louis M Staudt; Charles L Sawyers
Journal:  N Engl J Med       Date:  2017-05-25       Impact factor: 91.245

4.  Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling.

Authors:  Rebecca J Rockett; Alicia Arnott; Connie Lam; Rosemarie Sadsad; Verlaine Timms; Karen-Ann Gray; John-Sebastian Eden; Sheryl Chang; Mailie Gall; Jenny Draper; Eby M Sim; Nathan L Bachmann; Ian Carter; Kerri Basile; Roy Byun; Matthew V O'Sullivan; Sharon C-A Chen; Susan Maddocks; Tania C Sorrell; Dominic E Dwyer; Edward C Holmes; Jen Kok; Mikhail Prokopenko; Vitali Sintchenko
Journal:  Nat Med       Date:  2020-07-09       Impact factor: 53.440

5.  Cost of exome sequencing in epileptic encephalopathy: is it 'worth it'?

Authors:  Eva B Forman; Kathleen M Gorman; Judith Conroy; Neil Arthur; Ciara Grant; Sean Ennis; Nicholas M Allen; Sally Ann Lynch; Mary D King
Journal:  Arch Dis Child       Date:  2017-09-22       Impact factor: 3.791

6.  Enabling Equal Access to Molecular Diagnostics: What Are the Implications for Policy and Health Technology Assessment?

Authors:  Juliette Plun-Favreau; Kaisa Immonen-Charalambous; Lotte Steuten; Anja Strootker; Roman Rouzier; Denis Horgan; Mark Lawler
Journal:  Public Health Genomics       Date:  2016-06-01       Impact factor: 2.000

7.  Wide disparity of clinical genetics services and EU rare disease research funding across Europe.

Authors:  Sally Ann Lynch; Isabella Borg
Journal:  J Community Genet       Date:  2015-11-04

8.  The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.

Authors:  Edmund Gilbert; Seamus O'Reilly; Michael Merrigan; Darren McGettigan; Anne M Molloy; Lawrence C Brody; Walter Bodmer; Katarzyna Hutnik; Sean Ennis; Daniel J Lawson; James F Wilson; Gianpiero L Cavalleri
Journal:  Sci Rep       Date:  2017-12-08       Impact factor: 4.379

Review 9.  Practical approach to the diagnosis of adult-onset leukodystrophies: an updated guide in the genomic era.

Authors:  David S Lynch; Charles Wade; Anderson Rodrigues Brandão de Paiva; Nevin John; Justin A Kinsella; Áine Merwick; Rebekah M Ahmed; Jason D Warren; Catherine J Mummery; Jonathan M Schott; Nick C Fox; Henry Houlden; Matthew E Adams; Indran Davagnanam; Elaine Murphy; Jeremy Chataway
Journal:  J Neurol Neurosurg Psychiatry       Date:  2018-11-22       Impact factor: 10.154

Review 10.  Value-based genomics.

Authors:  Jun Gong; Kathy Pan; Marwan Fakih; Sumanta Pal; Ravi Salgia
Journal:  Oncotarget       Date:  2018-01-30
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  1 in total

1.  A pilot study investigating feasibility of mainstreaming germline BRCA1 and BRCA2 testing in high-risk patients with breast and/or ovarian cancer in three tertiary Cancer Centres in Ireland.

Authors:  Terri Patricia McVeigh; Karl J Sweeney; Donal J Brennan; Una M McVeigh; Simon Ward; Ann Strydom; Sheila Seal; Katherine Astbury; Paul Donnellan; Joanne Higgins; Maccon Keane; Michael J Kerin; Carmel Malone; Pauline McGough; Ray McLaughlin; Michael O'Leary; Margaret Rushe; Michael Kevin Barry; Geraldine MacGregor; Michael Sugrue; Ala Yousif; Dhafir Al-Azawi; Eileen Berkeley; Terence J Boyle; Elizabeth M Connolly; Carmel Nolan; Elaine Richardson; Claire Giffney; Samantha B Doyle; Sheila Broderick; William Boyd; Ruaidhri McVey; Thomas Walsh; Michael Farrell; David J Gallagher; Nazneen Rahman; Angela J George
Journal:  Fam Cancer       Date:  2022-08-27       Impact factor: 2.446

  1 in total

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