Literature DB >> 33855166

Targeting gliomas with STAT3-silencing nanoparticles.

Padma Kadiyala1,2, Jason V Gregory3,4, Pedro R Lowenstein1,2,3, Joerg Lahann3,4,5, Maria G Castro1,2,3.   

Abstract

Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood-brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice.
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

Entities:  

Keywords:  Glioma; nanoparticles; immunotherapy; systemic drug-delivery; targeted-therapy

Year:  2021        PMID： 33855166      PMCID： PMC8018361          DOI： 10.1080/23723556.2020.1870647

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012.

Authors:  Quinn T Ostrom; Haley Gittleman; Jordonna Fulop; Max Liu; Rachel Blanda; Courtney Kromer; Yingli Wolinsky; Carol Kruchko; Jill S Barnholtz-Sloan
Journal:  Neuro Oncol       Date:  2015-10-27       Impact factor: 12.300

Review 2.  Targeting the IL-6/JAK/STAT3 signalling axis in cancer.

Authors:  Daniel E Johnson; Rachel A O'Keefe; Jennifer R Grandis
Journal:  Nat Rev Clin Oncol       Date:  2018-02-06       Impact factor: 66.675

3.  A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma.

Authors:  Manfred Westphal; Dana C Hilt; Enoch Bortey; Patrick Delavault; Robert Olivares; Peter C Warnke; Ian R Whittle; Juha Jääskeläinen; Zvi Ram
Journal:  Neuro Oncol       Date:  2003-04       Impact factor: 12.300

Review 4.  Glioblastoma multiforme: Pathogenesis and treatment.

Authors:  Constantinos Alifieris; Dimitrios T Trafalis
Journal:  Pharmacol Ther       Date:  2015-05-02       Impact factor: 12.310

5.  Dual-stimuli-responsive microparticles.

Authors:  Ekaterina Sokolovskaya; Sahar Rahmani; Asish C Misra; Stefan Bräse; Joerg Lahann
Journal:  ACS Appl Mater Interfaces       Date:  2015-04-30       Impact factor: 9.229

6.  Tissue-penetrating delivery of compounds and nanoparticles into tumors.

Authors:  Kazuki N Sugahara; Tambet Teesalu; Priya Prakash Karmali; Venkata Ramana Kotamraju; Lilach Agemy; Olivier M Girard; Douglas Hanahan; Robert F Mattrey; Erkki Ruoslahti
Journal:  Cancer Cell       Date:  2009-12-08       Impact factor: 31.743

7.  The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.

Authors:  Mohamed Abou-Ghazal; David S Yang; Wei Qiao; Chantal Reina-Ortiz; Jun Wei; Ling-Yuan Kong; Gregory N Fuller; Nobuyoshi Hiraoka; Waldemar Priebe; Raymond Sawaya; Amy B Heimberger
Journal:  Clin Cancer Res       Date:  2008-12-15       Impact factor: 12.531

8.  Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy.

Authors:  Hikmat H Assi; Chris Paran; Nathan VanderVeen; Jonathan Savakus; Robert Doherty; Emanuele Petruzzella; James D Hoeschele; Henry Appelman; Leda Raptis; Tom Mikkelsen; Pedro R Lowenstein; Maria G Castro
Journal:  J Pharmacol Exp Ther       Date:  2014-04-02       Impact factor: 4.030

9.  Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis.

Authors:  Li Sun; Qianqian Wang; Bin Chen; Yuanyuan Zhao; Bo Shen; Hua Wang; Jing Xu; Miaolin Zhu; Xiangdong Zhao; Changgen Xu; Zhihong Chen; Mei Wang; Wenrong Xu; Wei Zhu
Journal:  Cell Death Dis       Date:  2018-09-11       Impact factor: 8.469

10.  Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy.

Authors:  Jason V Gregory; Padma Kadiyala; Robert Doherty; Melissa Cadena; Samer Habeel; Erkki Ruoslahti; Pedro R Lowenstein; Maria G Castro; Joerg Lahann
Journal:  Nat Commun       Date:  2020-11-10       Impact factor: 14.919
  10 in total
  1 in total

Review 1.  Transcription Factors with Targeting Potential in Gliomas.

Authors:  Angeliki-Ioanna Giannopoulou; Dimitrios S Kanakoglou; Christina Piperi
Journal:  Int J Mol Sci       Date:  2022-03-28       Impact factor: 5.923
  1 in total

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