Research Trends in General Medicine Departments of University Hospitals in Japan.

PURPOSE: The training of generalist physicians in university hospitals needs to emphasize development of their research role in order to continue improving their research capacity and their standing in academic hospitals in Japan. This cross-sectional descriptive study aimed to survey departments of general medicine (GM) in university hospitals in Japan to identify the research areas and themes pursued by academic generalist physicians. PATIENTS AND METHODS: The heads of the departments of GM from 71 university hospitals in Japan were enrolled. The main outcomes studied were the identification of the main research areas and themes in academic departments of GM, based on the classification of the National Grants-in-Aid for Scientific Research (KAKENHI): clinical research, public health, preventive medicine, medical education, basic science, health services and safety and quality.
RESULTS: We received 47 of 71 replies (66.2% response rate). Clinical research was the most common area of research (62%), followed by public health and preventive medicine (14%), medical education (11%), and basic sciences (9%). Only one department identified health services and safety and quality as a research area (2%). There was marked variability in research areas across the different departments, with 23% of the research targeting the highest specialties, particularly organ-specific research in the fields of gastroenterology, cardiology, immunology, neurology, metabolic endocrinology, and hematology-oncology.
CONCLUSION: The training of generalist physicians in university hospitals needs to emphasize development of their research role in order to continue improving the research capacity and the standing generalist physicians in academic hospitals in Japan.

Introduction

It is essential that generalist physicians be actively involved in research to improve patient care quality, promote patient-centered care, and, importantly, develop and promote general medicine (GM) as an academic discipline. However, internationally, the contribution of generalist physicians to research is not as high as that of other subspecialists.1–3 The field of practice of generalist physicians has been classified into family, general, and hospital medicine, with the definition and classification varying between countries and different healthcare systems.3–5 In Japan, the generalist physician role was established as one of the 19 medical board subspecialties only in 2018.6 The role of generalist physicians in Japan is varied, including hospital medicine, family medicine, outpatient management of difficult diagnostic cases, or a mix of these roles. Therefore, the definition and actual role of generalists within Japan’s unique healthcare system has not yet been clearly established,7 with generalists adapting their role depending on the needs of clinical settings in which they work. This has resulted in difficulty for generalist physicians to become active in research in university hospitals.5,8 Wachter and Goldman3 identified the burden of teaching as a potential barrier to generalists in becoming involved in research. Specifically, the clinical success of generalists has led to a large increase in their recruitment in hospitals, with a large focus of their contribution being to teaching in academic hospitals. With regard to research, generalists contribute to clinical research, health services, quality, and safety and clinical education research, all of which require a cross-sectional and comprehensive perspective which aligns with their training.8,9 Through research, generalists have provided evidence to support the benefits and safety of their practice.10 However, in Japan, the research involvement of generalist physicians has not been clearly defined. Therefore, our aim was to survey departments of GM in university hospitals in Japan to identify the research areas and themes pursued by academic generalist physicians. This is an important issue if we are to better describe the roles and contributions of generalist physicians in Japan.

Methods

This was a cross-sectional descriptive study of all GM departments in the 71 university hospitals in Japan (Tertiary hospital). Our survey was distributed by the Council of Japanese university hospitals, between June 1 and July 17, 2020. The survey was conducted among department heads for accurate documentation of the main research area in their department, defined based on the classification of the National Grants-in-Aid for Scientific Research (KAKENHI),11 as follows: clinical research, public health, preventive medicine, medical education, basic science, health services and safety and quality. The data were collected through an online platform. Surveys returned with incomplete information or inappropriate descriptions were excluded from our analysis.

Ethics approval was not required owing to our use of surveys; it was made clear at the start of the survey that no personal information was being collected and that university data would be anonymized.

Results

Complete surveys were returned by 47 of the 71 departments surveyed (66.2% response rate). Of these 47 participating departments, 31 were affiliated with public medical schools and the other 16 with private medical schools. The academic position of those responsible for completing this survey was as follows: Professor (n=35), Associate Professor (n=4), Lecturer (n=6), Assistant Professor (n=2). The distribution of the type of research undertaken by generalist physicians is shown in Figure 1. Clinical research was the most common area of research (62%), followed by public health and preventive medicine (14%), medical education (11%), and basic sciences (9%). Only one department identified health services, safety, and quality as a research area (2%). Note, the research area for one center was not specified (2%). The specific research themes, as per the KAKENHI classification, are reported in Table 1. On average, one department of GM reported being involved in 1.5 research themes, with research in general internal medicine being the most common (n=20), followed by medical management and medical sociology (n=11), and infectious disease medicine (n=5). There was marked variability in the areas of research across the different departments, with 23% of the research targeting the highest specialties, particularly organ-specific research in the fields of gastroenterology, cardiology, immunology, neurology, metabolic endocrinology, and hematology-oncology.

Figure 1

Types of research fields identified by the General Medicine departments in our 2020 survey.

Table 1

Research themes of General Medicine departments of university hospitals classified using the Review Section of the Japanese KAKENHI classification

Section Number*	Basic Section	n
52010	General internal medicine	20
58010	Medical management and medical sociology	11
54030	Infectious disease medicine	5
53010	Gastroenterology	4
58030	Hygiene and public health-related: excluding laboratory approach	4
53020	Cardiology	3
54040	Metabolism and endocrinology	3
49070	Immunology	2
55060	Emergency medicine	2
58020	Hygiene and public health-related: including laboratory approach	2
58080	Gerontological nursing and community health nursing	2
10020	Educational psychology	1
50020	Tumor diagnostics and therapeutics	1
52020	Neurology	1
53030	Respiratory medicine	1
54010	Hematology and medical oncology	1
59010	Rehabilitation science	1
59040	Nutrition science and health science	1
90130	Medical systems	1
90140	Medical technology assessment	1
08020	Social welfare	1
09050	Tertiary education	1

Note: *Classification number of the Review Section of the Japanese KAKENHI.

Discussion

This was a cross-sectional survey of the areas and themes of research undertaken in departments of GM of university hospitals in Japan. As previously stated, understanding the research areas of generalist physicians is important to better define their role within academic hospitals, particularly in Japan where the generalist subspecialty is new and not yet well defined in term of scope. The role of generalist physicians has been better defined in European countries and in the United States, where generalists are regrouped under the umbrella terms of family medicine, general internal medicine, and hospital medicine.3–5,12 The need to better define the role of generalists is essential for appropriate allocation of medical resources, considering the different and often competing, demands within medical systems, and to appropriately address the barriers limiting the contribution of generalists to research in university hospitals.3,8,9,12 A previous report on the 25-year history of generalist physicians in the United States12 identified the following key factors as important for generalists to define their relevance and standing in hospitals: exerting institutional influence and prestige; faculty development; assuming leadership roles in medicine; defined clinical responsibilities; financial stability of GM departments; research productivity; and developing the field as an academic discipline. In the United States, GM has achieved its academic status through general physicians’ significant contributions to clinical practice and medical education.1,13,14 On the other hand, several studies show that research contribution by GM physicians has been limited.13,14 The GM departments of university hospital are expected to contribute to research, in addition to the above stated contribution to practice and education, to enhance the role and value of GM departments.15 With regard to research, the research interests of hospitalists is generally in clinical research, health services, quality improvement, and education.5,12 However, traditionally, the research direction for Departments of GM in hospitals has been in basic biomedical research. Yet, the area of research for generalists in hospitals is rarely in basic laboratory medicine,8 which may pose a further barrier to generalists in establishing a program of research in their specialty. As the medical training of generalists intersects with various medical subspecialties, generalists are well-positioned to contribute to research on health services, quality, and safety; health information, eg diagnostic error, patient safety, quality improvement, and clinical education.7

In Japan, generalist medicine physicians have an overall low contribution to research, with only 4.7% of the research presented at the Japan Primary Care Association, the largest society for general practitioners in Japan, being ultimately published in a peer-review journal, a rate that is noticeably lower than that of other medical departments.15 Two issues are important to consider in this regard. First, as the heads of GM departments are often from various internal medicine specialties, the focus on basic sciences research is likely to persist.7,14,15 The second issue regards mentorship which is important to support generalists in developing a program of research; however, as the generalist program became a medical board subspecialty in Japan only in 2018, the generalist subspecialty is still in its developmental stage and, thus, mentorship for research may not be readily available.7,8,11,14

The limitations of our study need to be acknowledged. Foremost is the possibility of a selection bias as we did not obtain responses from all university hospitals. In addition, we note that identified areas of research on our survey may not align with the allocation of research funds. Without information on funding, it is not possible at this time to fully compare the research capacity of generalists in Japan to that in other countries. The results of this survey may also be influenced by the field of study and practice of the principal author. Moreover, in Japan, national universities are regrouped under the umbrella of one university hospital and chair, with only some private universities having a chair in some hospital branches. This organization would influence the range of research conducted by Departments of GM in Japan.

Conclusion

This is the first study to report on the current research interests and trends in the departments of GM at university hospitals in Japan. Based on our findings and considering previous reports, we believe that research needs to be emphasized within the role of generalists in university hospitals in order to continue improving the contribution of standing generalists in academic hospitals in Japan. Previous findings from the United States may help in this regard, providing evidence that generalist physicians are well-positioned to contribute to research on health services, quality, and safety; health information; and clinical education.