Studies on the effects of the pineal hormone melatonin on an androgen-insensitive rat prostatic adenocarcinoma, the Dunning R 3327 HIF tumor.

The effects of the pineal indole melatonin on a transplantable androgen-insensitive fast-growing rat prostatic adenocarcinoma, the Dunning R 3327 HIF tumor, were examined. Afternoon injections of melatonin given to intact male rats enhanced tumor growth, while leading to a reduction in the weights of gonads and dorsal and ventral prostates. In anosmic hosts, this treatment had no effect on tumor growth or reproductive organ size. In castrated anosmic hosts, melatonin injections led to reductions in the growth of tumors, when compared with those in castrated hosts. Continuously available melatonin, in beeswax pellets, had no effect on growth of these tumors. These results are discussed in relation to the anticancer effects of melatonin and the effects of tumors on endogenous melatonin rhythms.