Afia Amoako1, David Ortiz-Paredes2, Kim Engler3, Bertrand Lebouché4, Marina B Klein5. 1. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, 1020 Pine Avenue West Montreal, Quebec, H3A 1A2, Canada. Electronic address: afia.amoako@mail.mcgill.ca. 2. Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve Montreal, H4A 3S5, Canada. Electronic address: david.ortiz-paredes@muhc.mcgill.ca. 3. Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve Montreal, H4A 3S5, Canada. Electronic address: kim.engler@muhc.mcgill.ca. 4. Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve Montreal, H4A 3S5, Canada; Department of Family Medicine, McGill University, 5858 Côte-des-Neiges Road Montreal, Quebec, H3S 1Z1, Canada; Department of Medicine, Division of Infectious Diseases/Chronic Viral Illness Service, Glen site, McGill University Health Centre, 1001, Decarie Boulevard - D02.4110, Montreal, Quebec, H4A 3J1, Canada; Canadian Institutes of Health Research Strategy for Patient-Oriented Research (CIHR/SPOR) Mentorship Chair in Innovative Clinical Trials in HIV, Montreal, Canada. Electronic address: bertrand.lebouche@mcgill.ca. 5. Department of Medicine, Division of Infectious Diseases/Chronic Viral Illness Service, Glen site, McGill University Health Centre, 1001, Decarie Boulevard - D02.4110, Montreal, Quebec, H4A 3J1, Canada; CIHR Canadian HIV Trials Network, 588 - 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada. Electronic address: marina.klein@mcgill.ca.
Abstract
BACKGROUND: Direct acting antivirals (DAAs) have increased cure rates for hepatitis C virus (HCV) infection; however, there are several obstacles to the uptake of DAAs in populations where substance use contributes to HCV risk. This synthesis aimed to identify the patient and provider perceived barriers and facilitators to DAA treatment initiation in key patient subgroups-people who inject drugs (PWID), men who have sex with men (MSM), and Indigenous people. METHODS: We systematically searched seven databases and conducted a gray literature search for studies that qualitatively explored patient and provider perceived barriers and facilitators to DAA treatment in our populations of interest. Selected studies were published after 2013 when second generation DAAs became available. The titles, abstracts, and subsequently full texts were screened by two independent reviewers and critically appraised. Barriers and facilitators to DAA treatment uptake were then extracted and thematically synthesized. RESULTS: 2144 titles and abstracts were identified and screened; 29 full texts were subsequently reviewed. Twelve qualitative studies were finally included. Among providers, perceived barriers to DAA treatment uptake included lack of resources and lack of provider knowledge on HCV while facilitators to treatment provision included simplicity of DAA regimens and professional identity as a doctor to advocate for patients. Among patients, perceived barriers to treatment uptake included current drug use, concerns about side effects of DAAs, stigma, gaps in community care, competing social responsibilities and mental health issues while facilitators included having a trustworthy provider and access to multidisciplinary HCV care. CONCLUSION: Despite simplicity of DAAs, many structural barriers to optimal HCV care continue to be experienced by patients and providers. In highlighting nuanced patient and provider perceived barriers and facilitators, this review underscores the need to involve participatory methods in the design and evaluation of interventions to best improve access to care.
BACKGROUND: Direct acting antivirals (DAAs) have increased cure rates for hepatitis C virus (HCV) infection; however, there are several obstacles to the uptake of DAAs in populations where substance use contributes to HCV risk. This synthesis aimed to identify the patient and provider perceived barriers and facilitators to DAA treatment initiation in key patient subgroups-people who inject drugs (PWID), men who have sex with men (MSM), and Indigenous people. METHODS: We systematically searched seven databases and conducted a gray literature search for studies that qualitatively explored patient and provider perceived barriers and facilitators to DAA treatment in our populations of interest. Selected studies were published after 2013 when second generation DAAs became available. The titles, abstracts, and subsequently full texts were screened by two independent reviewers and critically appraised. Barriers and facilitators to DAA treatment uptake were then extracted and thematically synthesized. RESULTS: 2144 titles and abstracts were identified and screened; 29 full texts were subsequently reviewed. Twelve qualitative studies were finally included. Among providers, perceived barriers to DAA treatment uptake included lack of resources and lack of provider knowledge on HCV while facilitators to treatment provision included simplicity of DAA regimens and professional identity as a doctor to advocate for patients. Among patients, perceived barriers to treatment uptake included current drug use, concerns about side effects of DAAs, stigma, gaps in community care, competing social responsibilities and mental health issues while facilitators included having a trustworthy provider and access to multidisciplinary HCV care. CONCLUSION: Despite simplicity of DAAs, many structural barriers to optimal HCV care continue to be experienced by patients and providers. In highlighting nuanced patient and provider perceived barriers and facilitators, this review underscores the need to involve participatory methods in the design and evaluation of interventions to best improve access to care.
Authors: David Ortiz-Paredes; Afia Amoako; Taline Ekmekjian; Kim Engler; Bertrand Lebouché; Marina B Klein Journal: Front Public Health Date: 2022-06-24
Authors: Shelley N Facente; Rachel Grinstein; Roberta Bruhn; Zhanna Kaidarova; Erin Wilson; Jennifer Hecht; Katie Burk; Eduard Grebe; Meghan D Morris Journal: PLoS One Date: 2022-05-11 Impact factor: 3.752