Literature DB >> 338534

Transmethylation hypothesis of schizophrenia: methionine and nicotinic acid.

J N Nestoros, T A Ban, H E Lehmann.   

Abstract

The transmethylation hypothesis of schizophrenia was reviewed with considerations that large doses of methionine when combined with a monoamine oxidase inhibitor lead to exacerbation of psychotic symptoms in a significant percentage of chronic schizophrenic patients. It was noted that nicotinic acid in the dosage of 3,000 mg/day can neither prevent nor counteract the psychopathology thus induced.

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Year:  1977        PMID: 338534     DOI: 10.1159/000468311

Source DB:  PubMed          Journal:  Int Pharmacopsychiatry        ISSN: 0020-8272


  3 in total

Review 1.  Dietary thiols in exercise: oxidative stress defence, exercise performance, and adaptation.

Authors:  Yanita McLeay; Stephen Stannard; Stuart Houltham; Carlene Starck
Journal:  J Int Soc Sports Nutr       Date:  2017-04-27       Impact factor: 5.150

Review 2.  5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders.

Authors:  Hridya Jayamohananan; Maneesha Kalappurackal Manoj Kumar; Aneesh T P
Journal:  Adv Pharm Bull       Date:  2019-08-01

3.  Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice.

Authors:  Cheril Tapia-Rojas; Carolina B Lindsay; Carla Montecinos-Oliva; Macarena S Arrazola; Rocio M Retamales; Daniel Bunout; Sandra Hirsch; Nibaldo C Inestrosa
Journal:  Mol Neurodegener       Date:  2015-11-21       Impact factor: 14.195

  3 in total

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