Jean-Louis Vincent1, Jan Bakker2,3,4,5. 1. Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium. 2. Department of Intensive Care, Erasmus MC - University Medical Center, Rotterdam, The Netherlands. 3. Department of Pulmonology and Critical Care, New York University NYU Langone Medical Center. 4. Department of Pulmonology and Critical Care, Columbia University Medical Center, New York, USA. 5. Pontificia Universidad Católica de Chile, Department of Intensive Care, Santiago, Chile.
Abstract
PURPOSE OF REVIEW: Blood lactate concentrations are frequently measured in critically ill patients and have important prognostic value. Here, we review some key questions related to their clinical use in sepsis. RECENT FINDINGS: Despite the metabolic hurdles, measuring lactate concentrations remains very informative in clinical practice. Although blood lactate levels change too slowly to represent the only guide to resuscitation, serial lactate levels can help to define the patient's trajectory and encourage a review of the therapeutic strategy if they remain stable or increase over time. SUMMARY: Lactate concentrations respond too slowly to be used to guide acute changes in therapy, but can help evaluate overall response. Hyperlactatemia should not be considered as a problem in itself, but as a warning of altered cell function.
PURPOSE OF REVIEW: Blood lactate concentrations are frequently measured in critically illpatients and have important prognostic value. Here, we review some key questions related to their clinical use in sepsis. RECENT FINDINGS: Despite the metabolic hurdles, measuring lactate concentrations remains very informative in clinical practice. Although blood lactate levels change too slowly to represent the only guide to resuscitation, serial lactate levels can help to define the patient's trajectory and encourage a review of the therapeutic strategy if they remain stable or increase over time. SUMMARY:Lactate concentrations respond too slowly to be used to guide acute changes in therapy, but can help evaluate overall response. Hyperlactatemia should not be considered as a problem in itself, but as a warning of altered cell function.
Authors: Tae Seok Oh; Manal Zabalawi; Shalini Jain; David Long; Peter W Stacpoole; Charles E McCall; Matthew A Quinn Journal: JCI Insight Date: 2022-06-22
Authors: Dustin Beyer; Jessica Hoff; Oliver Sommerfeld; Alexander Zipprich; Nikolaus Gaßler; Adrian T Press Journal: Mol Med Date: 2022-07-30 Impact factor: 6.376