Basem Saleh1,2, Mohamed A Elhawary3,4, Moataz E Mohamed5, Islam N Ali4,6, Menna S El Zayat7, Hadeer Mohamed8,9. 1. Medical Oncology Department, Tanta Cancer Center, Ministry of Health, Tanta, Gharbiah, Egypt. 2. Medical Oncology Department, Aswan Oncology Center, Ministry of Health, Aswân, Egypt. 3. International Society of Pharmacovigilance - Egypt Chapter, Cairo, Egypt. 4. Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. 5. Department of Pharmacy Practice, Faculty of Pharmacy, Helwan University, Cairo, Egypt. 6. University of Glasgow, Glasgow, Scotland, UK. 7. Diagnostic Radiology Department, Al Helal Hospital - Specialized Medical Centers, Cairo, Egypt. 8. Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. hadeerhesham12@gmail.com. 9. Department of Clinical Oncology, Ain Shams University Hospitals, Cairo, Egypt. hadeerhesham12@gmail.com.
Abstract
PURPOSE: Herein, our purpose was to calculate the 5-year and lifetime risk of breast cancer and to assess new breast cancer potential contributors among Egyptian women utilizing the modified Gail model, while presenting a global comparison of risk assessment. METHODS: This study included 7009 women from both urban and rural areas scattered across 40% of the Egyptian provinces. The 5-year risk categories were defined as low risk (≤ 1.66%) or high risk (> 1.66%), whereas the lifetime risk categories were defined as low risk (≤ 20%) or high risk (> 20%). Pearson's Chi-squared test was performed to determine the association between participants' characteristics and distinct risk categories. Binary logistic regression was carried out for correlation analysis. RESULTS: The mean estimated risk for developing invasive breast cancer over 5 years was 0.86 (± 0.67), whereas the mean lifetime breast cancer risk score was 11.26 (± 5.7). Accordingly, only 614 (8.75%) and 470 (6.7%) women were categorized as individuals with high risk of breast cancer incidence in 5-year and lifetime, respectively. Only 192 participants (2.7%) conferred both high 5-year and high lifetime risk scores. Marital status, method of feeding, physical activity behavior, contraceptive use, menopause and number of children were found to have a statistically significant association with both 5-year and lifetime breast cancer risk categories. CONCLUSION: We revealed that modified Gail model had a well-fitting and discrimination accuracy in Egyptian women when compared with other countries.
PURPOSE: Herein, our purpose was to calculate the 5-year and lifetime risk of breast cancer and to assess new breast cancer potential contributors among Egyptian women utilizing the modified Gail model, while presenting a global comparison of risk assessment. METHODS: This study included 7009 women from both urban and rural areas scattered across 40% of the Egyptian provinces. The 5-year risk categories were defined as low risk (≤ 1.66%) or high risk (> 1.66%), whereas the lifetime risk categories were defined as low risk (≤ 20%) or high risk (> 20%). Pearson's Chi-squared test was performed to determine the association between participants' characteristics and distinct risk categories. Binary logistic regression was carried out for correlation analysis. RESULTS: The mean estimated risk for developing invasive breast cancer over 5 years was 0.86 (± 0.67), whereas the mean lifetime breast cancer risk score was 11.26 (± 5.7). Accordingly, only 614 (8.75%) and 470 (6.7%) women were categorized as individuals with high risk of breast cancer incidence in 5-year and lifetime, respectively. Only 192 participants (2.7%) conferred both high 5-year and high lifetime risk scores. Marital status, method of feeding, physical activity behavior, contraceptive use, menopause and number of children were found to have a statistically significant association with both 5-year and lifetime breast cancer risk categories. CONCLUSION: We revealed that modified Gail model had a well-fitting and discrimination accuracy in Egyptian women when compared with other countries.
Entities:
Keywords:
Breast cancer; Egypt; Gail Model; Risk assessment
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