Literature DB >> 33851342

Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells.

Malak Zoaiter1,2, Roudaina Nasser1, Rouba Hage-Sleiman1, Fadi Abdel-Sater3, Bassam Badran1, Zaher Zeaiter4.   

Abstract

Helicobacter pylori, a human pathogen that colonizes the stomach of 50% of the world's population, is associated with gastritis, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. Diseases are characterized by severe inflammatory responses in the stomach that are induced by various chemokines and cytokines. Recently, oncostatin M (OSM), an IL-6 family cytokine, was detected in early gastric cancer biopsies. In this study, we showed that Helicobacter pylori induced secretion of OSM and overexpression of its type II receptor OSMRβ (OSM/OSMRβ) in a human gastric adenocarcinoma cell line (AGS) over 24 h of infection. Furthermore, we showed that the induction of OSM and OSMRβ was carried out by heat-sensitive Helicobacter pylori outer membrane vesicle (OMV) protein. Collectively, our results established, for the first time, a direct relation between Helicobacter pylori OMVs and the OSM/OSMRβ signaling axis.
© 2021. Sociedade Brasileira de Microbiologia.

Entities:  

Keywords:  AGS cells; Gastric cancer; Helicobacter pylori; OMVs; OSM; OSMRβ

Mesh：

Substances：

Year:  2021        PMID： 33851342      PMCID： PMC8324738          DOI： 10.1007/s42770-021-00490-7

Source DB:  PubMed          Journal:  Braz J Microbiol        ISSN： 1517-8382            Impact factor:   2.476


  60 in total

1.  Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells.

Authors:  Maria Kaparakis; Lynne Turnbull; Leticia Carneiro; Stephen Firth; Harold A Coleman; Helena C Parkington; Lionel Le Bourhis; Abdulgader Karrar; Jérôme Viala; Johnson Mak; Melanie L Hutton; John K Davies; Peter J Crack; Paul J Hertzog; Dana J Philpott; Stephen E Girardin; Cynthia B Whitchurch; Richard L Ferrero
Journal:  Cell Microbiol       Date:  2009-11-02       Impact factor: 3.715

2.  The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.

Authors:  Aaron T Irving; Hitomi Mimuro; Thomas A Kufer; Camden Lo; Richard Wheeler; Lorinda J Turner; Belinda J Thomas; Christian Malosse; Michael P Gantier; Linda N Casillas; Bartholomew J Votta; John Bertin; Ivo G Boneca; Chihiro Sasakawa; Dana J Philpott; Richard L Ferrero; Maria Kaparakis-Liaskos
Journal:  Cell Host Microbe       Date:  2014-04-17       Impact factor: 21.023

3.  Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection.

Authors:  Esther Larrea; Itziar Echeverria; Jose-I Riezu-Boj; Rafael Aldabe; Laura Guembe; Iosu Sola; María Pilar Civeira; Pablo Sarobe; Jesus Prieto
Journal:  J Hepatol       Date:  2013-10-26       Impact factor: 25.083

Review 4.  Inflammation, Immunity, and Vaccine Development for the Gastric Pathogen Helicobacter pylori.

Authors:  Tamaki Ikuse; Thomas G Blanchard; Steven J Czinn
Journal:  Curr Top Microbiol Immunol       Date:  2019       Impact factor: 4.291

5.  Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load.

Authors:  M Mohammadi; J Nedrud; R Redline; N Lycke; S J Czinn
Journal:  Gastroenterology       Date:  1997-12       Impact factor: 22.682

6.  Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice.

Authors:  M Mohammadi; S Czinn; R Redline; J Nedrud
Journal:  J Immunol       Date:  1996-06-15       Impact factor: 5.422

7.  Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.

Authors:  Stacey R Dillon; Cindy Sprecher; Angela Hammond; Janine Bilsborough; Maryland Rosenfeld-Franklin; Scott R Presnell; Harald S Haugen; Mark Maurer; Brandon Harder; Janet Johnston; Susan Bort; Sherri Mudri; Joseph L Kuijper; Tom Bukowski; Pamela Shea; Dennis L Dong; Maria Dasovich; Francis J Grant; Luann Lockwood; Steven D Levin; Cosette LeCiel; Kim Waggie; Heather Day; Stavros Topouzis; Janet Kramer; Rolf Kuestner; Zhi Chen; Don Foster; Julia Parrish-Novak; Jane A Gross
Journal:  Nat Immunol       Date:  2004-06-06       Impact factor: 25.606

8.  Insights into the Staphylococcus aureus-host interface: global changes in host and pathogen gene expression in a rabbit skin infection model.

Authors:  Natalia Malachowa; Scott D Kobayashi; Daniel E Sturdevant; Dana P Scott; Frank R DeLeo
Journal:  PLoS One       Date:  2015-02-26       Impact factor: 3.240

Review 9.  Review: Pathogenesis of Helicobacter pylori infection.

Authors:  Magdalena Chmiela; Juozas Kupcinskas
Journal:  Helicobacter       Date:  2019-09       Impact factor: 5.753

Review 10.  Immune Response in H. pylori-Associated Gastritis and Gastric Cancer.

Authors:  Qingbin Niu; Jun Zhu; Xingquan Yu; Tao Feng; Hong Ji; Yuming Li; Weiwei Zhang; Baoguang Hu
Journal:  Gastroenterol Res Pract       Date:  2020-01-28       Impact factor: 2.260
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  2 in total

1.  Resveratrol Downregulates Granulocyte-Macrophage Colony-Stimulating Factor-Induced Oncostatin M Production through Blocking of PI3K/Akt/NF-κB Signal Cascade in Neutrophil-like Differentiated HL-60 Cells.

Authors:  Na-Ra Han; Hi-Joon Park; Phil-Dong Moon
Journal:  Curr Issues Mol Biol       Date:  2022-01-22       Impact factor: 2.976

2.  Dexamethasone Attenuates Oncostatin M Production via Suppressing of PI3K/Akt/NF-κB Signaling in Neutrophil-like Differentiated HL-60 Cells.

Authors:  Na-Ra Han; Seong-Gyu Ko; Hi-Joon Park; Phil-Dong Moon
Journal:  Molecules       Date:  2021-12-27       Impact factor: 4.411
  2 in total

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