Davide Zella1,2, Marta Giovanetti3, Eleonora Cella4, Alessandra Borsetti5, Marco Ciotti6, Giancarlo Ceccarelli7, Gabriella D'Ettorre7, Aldo Pezzuto8, Vittoradolfo Tambone9, Laura Campanozzi9, Marco Magheri10, Francesco Unali10, Martina Bianchi11, Francesca Benedetti1, Stefano Pascarella11, Silvia Angeletti12, Massimo Ciccozzi13. 1. Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, USA. 2. Member of the Global Virus Network, Baltimore, USA. 3. Flavivirus Laboratory, Oswaldo Cruz Institute Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. 4. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA. 5. National HIV/AIDS Research Center Istituto Superiore di Sanità, Rome, Italy. 6. Virology Unit, Laboratory of Clinical Microbiology and Virology, Polyclinic Tor Vergata Foundation, Rome, Italy. 7. Department of Public Health and Infectious Diseases, , Sapienza University of Rome, 00185 Rome, Italy. 8. Cardiovascular-Respiratory Science Department, Sant' Andrea Hospital-Sapienza University, Rome, Italy. 9. Institute of Philosophy of Scientific and Technological Practice, Campus Bio-Medico University, 00128 Rome, Italy. 10. Communication Division, University campus Bio-Medico of Rome. 11. Department of Biochemical Sciences "A. Rossi Fanelli," University of Rome "La Sapienza", Rome, Italy. 12. Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy. 13. Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy.
Abstract
Introduction: SARS-CoV-2 pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert Opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
Introduction: SARS-CoV-2 paene">ndemic has pushed the scientific commuene">nity to uene">ndertake iene">ntense research efforts. Understaene">ndiene">ng n class="Species">SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert Opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
Authors: Letizia Santinelli; Luca Laghi; Giuseppe Pietro Innocenti; Claudia Pinacchio; Paolo Vassalini; Luigi Celani; Alessandro Lazzaro; Cristian Borrazzo; Massimiliano Marazzato; Lorenzo Tarsitani; Alexia E Koukopoulos; Claudio M Mastroianni; Gabriella d'Ettorre; Giancarlo Ceccarelli Journal: Front Nutr Date: 2022-01-12