Literature DB >> 33848732

TRPA1 channel: New kid in the 'neurovascular coupling' town.

Maria Sancho1, Mark T Nelson2.   

Abstract

The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as 'neurovascular coupling' (NVC). In a recent publication (eLife 2021) Thakore et al. provide profound mechanistic insight how the capillary endothelial transient receptor potential ankyrin 1 (TRPA1) channel contribute to blood flow control and functional hyperemia in the brain. Published by Elsevier Ltd.

Entities:  

Keywords:  Calcium signaling; Capillary endothelium; Cerebral blood flow; Functional hyperemia; Neurovascular coupling; TRPA1 channels

Mesh：

Substances：

Year:  2021        PMID： 33848732      PMCID： PMC8628301          DOI： 10.1016/j.ceca.2021.102407

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   4.690


  7 in total

Review 1.  Transient receptor potential channels in the vasculature.

Authors:  Scott Earley; Joseph E Brayden
Journal:  Physiol Rev       Date:  2015-04       Impact factor: 37.312

2.  Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation.

Authors:  Michelle N Sullivan; Albert L Gonzales; Paulo W Pires; Allison Bruhl; M Dennis Leo; Wencheng Li; Agathe Oulidi; Frederick A Boop; Yumei Feng; Jonathan H Jaggar; Donald G Welsh; Scott Earley
Journal:  Sci Signal       Date:  2015-01-06       Impact factor: 8.192

3.  Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke.

Authors:  Paulo Wagner Pires; Scott Earley
Journal:  Elife       Date:  2018-09-21       Impact factor: 8.140

Review 4.  The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.

Authors:  Costantino Iadecola
Journal:  Neuron       Date:  2017-09-27       Impact factor: 17.173

5.  Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.

Authors:  Thomas A Longden; Fabrice Dabertrand; Masayo Koide; Albert L Gonzales; Nathan R Tykocki; Joseph E Brayden; David Hill-Eubanks; Mark T Nelson
Journal:  Nat Neurosci       Date:  2017-03-20       Impact factor: 24.884

6.  Brain endothelial cell TRPA1 channels initiate neurovascular coupling.

Authors:  Pratish Thakore; Michael G Alvarado; Sher Ali; Amreen Mughal; Paulo W Pires; Evan Yamasaki; Harry At Pritchard; Brant E Isakson; Cam Ha T Tran; Scott Earley
Journal:  Elife       Date:  2021-02-26       Impact factor: 8.140

7.  PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.

Authors:  Osama F Harraz; Thomas A Longden; David Hill-Eubanks; Mark T Nelson
Journal:  Elife       Date:  2018-08-07       Impact factor: 8.140
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.