Eun Kyo Ha1, Ju Hee Kim2, Eun Lee3, Myungsoon Sung4, Hye Mi Jee5, Hey Sung Baek2, Youn Ho Shin6, Na Hee Lee5, Man Yong Han5. 1. Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea. 2. Department of Pediatrics, Hallym University Kandong Sacred Heart Hospital, Seoul, Republic of Korea. 3. Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea. 4. Department of Pediatrics, Soon Chun Hyang University Gumi Hospital, Soon Chun Hyang University College of Medicine, Gumi, Republic of Korea. 5. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. 6. Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea.
Abstract
BACKGROUND: Associations between anemia and allergic diseases have been reported, but the relationship of iron deficiency with airway dysfunction in children remains unclear. We aimed to investigate the relationship between abnormal iron parameters and lung function in schoolchildren. METHODS: Four hundred and forty-five children (10-12 years-old) from 11 elementary schools in were enrolled. The relationships of different iron parameters (hemoglobin, serum iron, transferrin saturation, and serum ferritin) with lung function evaluated by impulse oscillometry (airways resistance at 5 Hz [Rrs5], 10 Hz [Rrs10], and the difference of Rrs5 and Rrs20 Hz [Rrs5-20]), and with exhaled nitric oxide (FeNO) were evaluated after adjustment for confounders including height, sex, and body mass index (BMI) z-score, and for additional covariates that could affect airway function. RESULTS: Total airway dysfunction represented by Rrs5 was reduced in participants with low serum iron level (aβ:-0.13, 95% CI: -0.23 to -0.03, P = 0.040) after adjustment for key confounders, but did not correlate with other iron profiles. Reduced oscillometric lung function recorded as Rrs5-20 were related with low serum iron , and high serum ferritin, but the results were inconsistent after multiple comparisons. Associations were not observed with serum hemoglobin. CONCLUSIONS: airway dysfunction represented as oscillomteric Rrs5. Our results suggest a relationship of reduced lung function with abnormal iron status in children. This article is protected by copyright. All rights reserved.
BACKGROUND: Associations between anemia and allergic diseases have been reported, but the relationship of iron deficiency with airway dysfunction in children remains unclear. We aimed to investigate the relationship between abnormal iron parameters and lung function in schoolchildren. METHODS: Four hundred and forty-five children (10-12 years-old) from 11 elementary schools in were enrolled. The relationships of different iron parameters (hemoglobin, serum iron, transferrin saturation, and serum ferritin) with lung function evaluated by impulse oscillometry (airways resistance at 5 Hz [Rrs5], 10 Hz [Rrs10], and the difference of Rrs5 and Rrs20 Hz [Rrs5-20]), and with exhaled nitric oxide (FeNO) were evaluated after adjustment for confounders including height, sex, and body mass index (BMI) z-score, and for additional covariates that could affect airway function. RESULTS: Total airway dysfunction represented by Rrs5 was reduced in participants with low serum iron level (aβ:-0.13, 95% CI: -0.23 to -0.03, P = 0.040) after adjustment for key confounders, but did not correlate with other iron profiles. Reduced oscillometric lung function recorded as Rrs5-20 were related with low serum iron , and high serum ferritin, but the results were inconsistent after multiple comparisons. Associations were not observed with serum hemoglobin. CONCLUSIONS: airway dysfunction represented as oscillomteric Rrs5. Our results suggest a relationship of reduced lung function with abnormal iron status in children. This article is protected by copyright. All rights reserved.
Entities:
Keywords:
Children; Impulse oscillometry; Lung function; pulmonary function Iron
Authors: Ju Hee Kim; Jin Ah Kim; Eun Kyo Ha; Hye Mi Jee; Seung Won Lee; Mo Kyung Jung; Sanghoo Lee; Yoon Ho Shin; Eun-Gyong Yoo; Man Yong Han Journal: BMC Pediatr Date: 2022-03-17 Impact factor: 2.125