Xinyuan Zhang1, Samantha A Molsberry2, Milena Pavlova3, Michael A Schwarzschild4, Alberto Ascherio2,5,6, Xiang Gao1. 1. Department of Nutritional Sciences, The Pennsylvania State University, University Park. 2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 3. Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts. 4. Department of Neurology, Massachusetts General Hospital, Boston. 5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 6. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Abstract
Importance: Previous studies conducted among patients with Parkinson disease (PD) reported that parasomnias other than rapid eye movement (REM) sleep behavior disorder (RBD), particularly sleepwalking (SW), are associated with PD severity. However, it remains unclear whether the presence of SW is associated with altered odds of having PD in a population-based study. Objective: To evaluate whether probable SW, either alone or co-occurring with probable RBD, is associated with higher odds of PD in men. Design, Setting, and Participants: This cross-sectional study included 25 694 men from the Health Professionals Follow-up Study, a population-based cohort of male health professionals in the US with information on probable SW and probable RBD. Data collection took place between January 2012 and June 2018, and data analysis took place from July 2020 to October 2020. Exposures: Probable SW and probable RBD were measured by questions adapted from the Mayo Sleep Questionnaire in 2012. Main Outcomes and Measures: PD, confirmed after review of medical records by a movement disorder specialist. Results: Of the 25 694 studied men (mean [SD] age, 75.6 [7.4] years), 223 (0.9%) had probable SW, 2720 (10.6%) had probable RBD, and 257 (1.0%) had PD. After adjusting for potential confounders (eg, age, smoking, caffeine intake, chronic disease status, and other sleep disorders), compared with individuals without probable SW and probable RBD, participants with probable SW, probable RBD, and both probable SW and probable RBD had higher odds of PD, (probable SW: odds ratio [OR], 4.80; 95% CI, 1.61-14.26; probable RBD: OR, 6.36; 95% CI, 4.83-8.37; both probable SW and probable RBD: OR, 8.44; 95% CI, 3.90-18.27). Conclusions and Relevance: In this cross-sectional study of a male population, probable sleep parasomnias, including both SW and RBD, were associated with higher odds of having PD. PD-related neurodegeneration may impair arousal regulation during sleep.
Importance: Previous studies conducted among patients with Parkinson disease (PD) reported that parasomnias other than rapid eye movement (REM) sleep behavior disorder (RBD), particularly sleepwalking (SW), are associated with PD severity. However, it remains unclear whether the presence of SW is associated with altered odds of having PD in a population-based study. Objective: To evaluate whether probable SW, either alone or co-occurring with probable RBD, is associated with higher odds of PD in men. Design, Setting, and Participants: This cross-sectional study included 25 694 men from the Health Professionals Follow-up Study, a population-based cohort of male health professionals in the US with information on probable SW and probable RBD. Data collection took place between January 2012 and June 2018, and data analysis took place from July 2020 to October 2020. Exposures: Probable SW and probable RBD were measured by questions adapted from the Mayo Sleep Questionnaire in 2012. Main Outcomes and Measures: PD, confirmed after review of medical records by a movement disorder specialist. Results: Of the 25 694 studied men (mean [SD] age, 75.6 [7.4] years), 223 (0.9%) had probable SW, 2720 (10.6%) had probable RBD, and 257 (1.0%) had PD. After adjusting for potential confounders (eg, age, smoking, caffeine intake, chronic disease status, and other sleep disorders), compared with individuals without probable SW and probable RBD, participants with probable SW, probable RBD, and both probable SW and probable RBD had higher odds of PD, (probable SW: odds ratio [OR], 4.80; 95% CI, 1.61-14.26; probable RBD: OR, 6.36; 95% CI, 4.83-8.37; both probable SW and probable RBD: OR, 8.44; 95% CI, 3.90-18.27). Conclusions and Relevance: In this cross-sectional study of a male population, probable sleep parasomnias, including both SW and RBD, were associated with higher odds of having PD. PD-related neurodegeneration may impair arousal regulation during sleep.
Authors: Alexander J Baumgartner; Clete A Kushida; Michael O Summers; Drew S Kern; Aviva Abosch; John A Thompson Journal: Front Neurol Date: 2021-10-28 Impact factor: 4.003