Prevalence and Genotype Distribution of High-risk HPV Infection among Women in Beijing, China.

Cervical cancer is highly associated with high-risk human papillomavirus (HPV) infection and genotype distribution of high-risk HPV(HR-HPV) infection varies greatly in different regions. Clinical specimens were collected from 46365 patients at Beijing Friendship Hospital, Capital Medical University from January 2017 to December 2020. HPV DNA genotype testing was performed using Real-time PCR. The infection rates based on disease group were compared using the chi-square test. The linear-by-linear association test and gamma value were used to assess the changes in HPV prevalence over calendar year and age group. A total of 10514 women were infected with HR-HPV, with an overall positive rate of 22.7%. The most prevalence HR-HPV types were HPV 52, 58, 16, 51 and 66 and HPV 59 had a higher prevalence except for HPV16, 58 and 52 in cervical cancer group. Single infection of HR-HPV was dominant among different diseases groups. The infection rate of HR-HPV decreased first and then increased from below 20 years old to over 60 years old. There were significant differences in the HR-HPV infection rates among the age and disease groups. Our findings demonstrate that the genotype distribution of HR-HPV varied with age and diseases. The HR-HPV genotypes prevalence were found to be directly useful for local governments to promote HPV targeted vaccination in the study region. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.