Chunrong Huang1,2, Youchao Yu1,2, Wei Du1,2, Yahui Liu1,2, Ranran Dai1,2, Ping Wang1,2, Chenhong Zhang3, Guochao Shi1,2. 1. Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197, Rui Jin Er Road, Shanghai, 200025, People's Republic of China. 2. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, 197, Rui Jin Er Road, Shanghai, 200025, People's Republic of China. 3. State Key Laboratory of Microbial Metabolism & Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800, Dongchuan Road, Shanghai, 200240, People's Republic of China.
Abstract
Aim: To describe gut microbiome and functional genes of asthma. Patients & methods: Fecal microbiome in controls, asthma patients with and without inhaled corticosteroid (ICS) treatment was determined. Results: Patients with ICS had lower abundance of Alloprevotella, unclassified_f_Lachnospiraceae and Lachnospiraceae_NC2004_group, higher abundance of Sutterella and Sphingomonas than patients without ICS. In all the asthma patients, there are microbial differences in aging distribution, different gender and different asthmatic phenotypes. Asthma patients without ICS treatment had more microbial genes related to geraniol degradation, ethylbenzene degradation and bladder cancer than controls; 15 pathways showed significant difference between asthma patients with and without ICS treatment. Conclusion: We found gut dysbiosis in asthma and different functional pathways associated with both asthma and ICS.
Aim: To describe gut microbiome and functional genes of asthma. Patients & methods: Fecal microbiome in controls, asthmapatients with and without inhaled corticosteroid (ICS) treatment was determined. Results:Patients with ICS had lower abundance of Alloprevotella, unclassified_f_Lachnospiraceae and Lachnospiraceae_NC2004_group, higher abundance of Sutterella and Sphingomonas than patients without ICS. In all the asthmapatients, there are microbial differences in aging distribution, different gender and different asthmatic phenotypes. Asthmapatients without ICS treatment had more microbial genes related to geraniol degradation, ethylbenzene degradation and bladder cancer than controls; 15 pathways showed significant difference between asthmapatients with and without ICS treatment. Conclusion: We found gut dysbiosis in asthma and different functional pathways associated with both asthma and ICS.
Entities:
Keywords:
asthma; functional genes; gut microbiome; inhaled corticosteroids