Long-term mortality of elderly patients after intensive care unit admission for COVID-19.

Dear Editor,

Community-acquired pneumonia in critically ill elderly is associated with higher long-term mortality: patients over 80 years old (y.o.) hospitalised in the intensive care unit (ICU) for respiratory infection had a tenfold increased risk of death 6 months post-hospitalisation [1]. Noteworthy, the number of elderly patients admitted to an ICU steadily increased, likely reflecting the aging population [2]. The coronavirus disease 2019 (COVID-19) pandemic has challenged the triage criteria for the elderly population for admission to an intensive care unit. On one hand, the ICU-bed shortage prompted to limit ICU admissions for very old patients; on the other hand, there was a risk of weighing patient age too strongly when considering treatment options. To carefully balance the treatment decisions for critically ill old patients, information on their outcomes after SARS-CoV-2 infection are needed. The aim of this nationwide study was to describe 6-month mortality of elderly patients (≥ 80 y.o.) after ICU admission with invasive mechanical ventilation for COVID-19.

We performed a cross-sectional study using data from the French hospital discharge database (HDD), exhaustive for all public and private hospitals. Patients were included according to the following criteria: adults (≥ 18 y.o.), with invasive mechanical ventilation, admitted in ICU between 2020-03-01 and 2020–05-31, with ICD-10 diagnosis code of COVID-19. No nominative, sensitive, or personal data of patients have been collected. The main outcome was the 6-month mortality, which was defined as death during the hospital stay or during one readmission over the 6-month follow-up. We used Kaplan–Meier estimates to describe the overall mortality and log-rank test to compare patients ≥ 80 y.o. with patients 65–79 y.o. and < 65y.o.

We included 480 COVID-19 ventilated patients ≥ 80 y.o. who were compared with 4,646 and 4,759 COVID-19 ventilated patients of 65–79 y.o. and < 65 y.o., respectively. Online Table 1 reports the baseline characteristics and specific care support provided in ICU. Mortality was 62.5% during the ICU stay and 72.1% at 6 months for COVID-19 ventilated patients ≥ 80 y.o. The Kaplan–Meier curves showed important and significant differences in mortality in the elderly as compared with the younger age classes (log-rank test < 0.0001, Fig. 1).

Fig. 1

Kaplan–Meier curves showing the cumulative probabilities of survival, up to 6 month after ICU stay of critically ill SARS-CoV-2-infected patients with invasive mechanical ventilation

This study has limitations. First, the mortality was estimated based on at-hospital mortality. Out-of-hospital deaths were not recorded, giving a potential underestimation of the actual mortality. However, based on data from the INSEE survey [3], we know that dying people in France mostly end up in a hospital. Second, elderly individuals are admitted to ICU if a high likelihood of survival is expected a priori. Indeed, elderly patients studied here were selected from a triage based on the appropriateness of ICU admission. Overall, the mortality is likely to be underestimated in our study. Third, the study is from the “first wave”, therapeutic approaches have evolved since.

Among critically ill COVID-19 patients ≥ 80 y.o. considered as having a potential benefit from an ICU admission, we observed a 6-month mortality of 72%. This mortality rate is in the upper end of recent literature focusing on older critically ill patients [4, 5]. These findings provide data for more informed goals-of-care discussions for critically ill elderly patients infected by SARS-CoV-2.

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 23 KB)