Seung Wan Suh1, You Joung Kim2, Kyung Phil Kwak3, Kiwon Kim4, Moon-Doo Kim5, Byung-Soo Kim6, Bong Jo Kim7, Shin Gyeom Kim8, Jeong Lan Kim9, Tae Hui Kim10, Seok Woo Moon11, Kyung Won Park12, Jong-Il Park13,14, Joon Hyuk Park15, Jae Nam Bae16, Jiyeong Seo17, Su Jeong Seong1, Sang Joon Son18, Il-Seon Shin19,20, Seung-Ho Ryu21, Kang Joon Lee22, Nam-Jin Lee23, Dong Young Lee24,25, Dong Woo Lee26, Seok Bum Lee27, Chang Uk Lee28,29, Sung Man Chang6, Hyun-Ghang Jeong30,31, Maeng Je Cho25, Seong-Jin Cho32, Jin Hyeong Jhoo33, Young Min Choe34, Ji Won Han35, Ki Woong Kim25,35,36. 1. Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. 2. National Institute of Dementia, Seongnam, Korea. 3. Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, Korea. 4. Department of Psychiatry, Veteran Health Service Medical Center, Seoul, Korea. 5. Department of Psychiatry, College of Medicine, Jeju National University, Jeju, Korea. 6. Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea. 7. Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju, Korea. 8. Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. 9. Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea. 10. Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, Korea. 11. Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju, Korea. 12. Department of Neurology, Dong-A University College of Medicine and Department of Translational Biomedical Sciences, Graduate School of Dong-A University, Busan, Korea. 13. Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Korea. 14. Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea. 15. Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea. 16. Department of Psychiatry, Inha University Hospital, Incheon, Korea. 17. Department of Psychiatry, Gyeongsang National University Changwon Hospital, Changwon, Korea. 18. Department of Psychiatry, Ajou University School of Medicine, Suwon, Korea. 19. Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. 20. Department of Psychiatry, Chonnam National University Hwasun Hospital, Hwasun, Korea. 21. Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Korea. 22. Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. 23. Department of Psychiatry, Jeonju City Welfare Hospital for the Elderly, Jeonju, Korea. 24. Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. 25. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea. 26. Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Korea. 27. Department of Psychiatry, Dankook University Hospital, Cheonan, Korea. 28. Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. 29. Catholic Agro-Medical Center, The Catholic University of Korea, Seoul, Korea. 30. Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. 31. Korea University Research Institute of Mental Health, Seoul, Korea. 32. Department of Psychiatry, Gachon University, School of Medicine, Incheon, Korea. 33. Department of Psychiatry, Kangwon National University, School of Medicine, Chuncheon, Korea. 34. Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea. 35. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea. 36. Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul, Korea.
Abstract
BACKGROUND: In many high-income Western countries, the prevalence of dementia had been reduced over the past decades. OBJECTIVE: We investigated whether the prevalence of all-cause dementia, Alzheimer's disease, vascular dementia, and mild cognitive impairment (MCI) had changed in Korea from 2008 to 2017. METHODS: Nationwide Survey on Dementia Epidemiology of Korea (NaSDEK) in 2008 and 2017 was conducted on representative elderly populations that were randomly sampled across South Korea. Both surveys employed a two-stage design (screening and diagnostic phases) and diagnosed dementia and MCI according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders and the consensus criteria from the International Working Group, respectively. The numbers of participants aged 65 years or older in the screening and diagnostic phases were 6,141 and 1,673 in the NaSDEK 2008 and 2,972 and 474 in the NaSDEK 2017, respectively. RESULTS: The age- and sex-standardized prevalence of all-cause dementia and Alzheimer's disease showed nonsignificant decrease (12.3% to 9.8%, odds ratio [OR] = 0.89, 95% confidence interval [CI] = 0.54-1.48 for all-cause dementia; 7.6% to 6.8%, OR [95% CI] = 0.91 [0.58-1.42] for Alzheimer's disease). Vascular dementia decreased in the young-old population aged less than 75 years (2.7% to 0.001%, OR [95% CI] = 0.04 [0.01-0.15]) and in women (1.9% to 0.5%, OR [95% CI] = 0.27 [0.10-0.72]) while MCI remained stable (25.3% to 26.2%, OR [95% CI] = 1.08 [0.67-1.73]). CONCLUSION: We found that the prevalence of dementia in Korea showed a nonsignificant decrease between 2008 and 2017.
BACKGROUND: In many high-income Western countries, the prevalence of dementia had been reduced over the past decades. OBJECTIVE: We investigated whether the prevalence of all-cause dementia, Alzheimer's disease, vascular dementia, and mild cognitive impairment (MCI) had changed in Korea from 2008 to 2017. METHODS: Nationwide Survey on Dementia Epidemiology of Korea (NaSDEK) in 2008 and 2017 was conducted on representative elderly populations that were randomly sampled across South Korea. Both surveys employed a two-stage design (screening and diagnostic phases) and diagnosed dementia and MCI according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders and the consensus criteria from the International Working Group, respectively. The numbers of participants aged 65 years or older in the screening and diagnostic phases were 6,141 and 1,673 in the NaSDEK 2008 and 2,972 and 474 in the NaSDEK 2017, respectively. RESULTS: The age- and sex-standardized prevalence of all-cause dementia and Alzheimer's disease showed nonsignificant decrease (12.3% to 9.8%, odds ratio [OR] = 0.89, 95% confidence interval [CI] = 0.54-1.48 for all-cause dementia; 7.6% to 6.8%, OR [95% CI] = 0.91 [0.58-1.42] for Alzheimer's disease). Vascular dementia decreased in the young-old population aged less than 75 years (2.7% to 0.001%, OR [95% CI] = 0.04 [0.01-0.15]) and in women (1.9% to 0.5%, OR [95% CI] = 0.27 [0.10-0.72]) while MCI remained stable (25.3% to 26.2%, OR [95% CI] = 1.08 [0.67-1.73]). CONCLUSION: We found that the prevalence of dementia in Korea showed a nonsignificant decrease between 2008 and 2017.