Fang Han1,2,3, Jun Li4, Xinheng Zhao1, Xiaoliang Li2,3, Pinghui Wei1,5, Yan Wang6,7. 1. Clinical College of Ophthalmology, Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin, 300020, China. 2. Department of Ophthalmology, The 1St People's Hospital of Yunnan Province, 157 Jinbi Road, Kunming, China. 3. Department of Ophthalmology, The Affiliated Hospital of Kunming Science and Technology University, 157 Jinbi Road, Kunming, China. 4. Department of Ophthalmology, The Second People's Hospital of Yunnan Province, 176 Qingnian Road, Kunming, China. 5. Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Tianjin, China. 6. Clinical College of Ophthalmology, Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin, 300020, China. wangyan7143@vip.sina.com. 7. Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Tianjin, China. wangyan7143@vip.sina.com.
Abstract
PURPOSE: To analyze intraocular pressure (IOP) and glaucoma-associated factors in children. METHODS: A total of 4438 children aged 7-16 years (2321 boys and 2117 girls) were included in this study. Various ophthalmologic [IOP, central corneal thickness (CCT), etc.] and demographic (body mass index, etc.) parameters were evaluated. RESULTS: IOP increased between the ages of 7 and 9 years, peaking at 9 years. IOP increased after reaching a trough at 11 years and subsequently stabilized after 14 years. Girls exhibited thinner CCT (534.28 ± 30.84 µm vs. 537.04 ± 31.33 µm, P = 0.003), thicker lens thickness (3.56 ± 0.21 mm vs. 3.54 ± 0.20 mm, P = 0.001), shorter axial length (22.91 ± 0.93 mm vs. 23.32 ± 0.89 mm, P < 0.001), shallower anterior chamber depth (2.92 ± 0.27 mm vs. 3.00 ± 0.26 mm, P < 0.001), higher refraction (- 0.57 ± 1.48 D vs. 0.16 ± 1.35 D, P < 0.001), and higher mean corneal curvature (43.77 ± 1.39 vs. 43.03 ± 1.35, P < 0.001). Multivariable analysis assessed the following IOP-associated factors: thicker CCT [standardized correlation coefficient (SRC) = 0.201, P < 0.001), deeper anterior chamber depth (SRC = 0.059, P = 0.009), shorter axial length (SRC = - 0.086, P = 0.036), lower mean corneal curvature (SRC = - 0.123, P < 0.001), higher refraction (SRC = - 0.090, P < 0.001). CONCLUSION: IOP fluctuated in children, and a trend toward a higher mean IOP between the ages of 9 and 11 years, which stabilized after 14 years, was observed. IOP was associated with CCT, anterior chamber depth, axial length, lens thickness, mean corneal curvature, spherical equivalent, and systolic blood pressure.
PURPOSE: To analyze intraocular pressure (IOP) and glaucoma-associated factors in children. METHODS: A total of 4438 children aged 7-16 years (2321 boys and 2117 girls) were included in this study. Various ophthalmologic [IOP, central corneal thickness (CCT), etc.] and demographic (body mass index, etc.) parameters were evaluated. RESULTS: IOP increased between the ages of 7 and 9 years, peaking at 9 years. IOP increased after reaching a trough at 11 years and subsequently stabilized after 14 years. Girls exhibited thinner CCT (534.28 ± 30.84 µm vs. 537.04 ± 31.33 µm, P = 0.003), thicker lens thickness (3.56 ± 0.21 mm vs. 3.54 ± 0.20 mm, P = 0.001), shorter axial length (22.91 ± 0.93 mm vs. 23.32 ± 0.89 mm, P < 0.001), shallower anterior chamber depth (2.92 ± 0.27 mm vs. 3.00 ± 0.26 mm, P < 0.001), higher refraction (- 0.57 ± 1.48 D vs. 0.16 ± 1.35 D, P < 0.001), and higher mean corneal curvature (43.77 ± 1.39 vs. 43.03 ± 1.35, P < 0.001). Multivariable analysis assessed the following IOP-associated factors: thicker CCT [standardized correlation coefficient (SRC) = 0.201, P < 0.001), deeper anterior chamber depth (SRC = 0.059, P = 0.009), shorter axial length (SRC = - 0.086, P = 0.036), lower mean corneal curvature (SRC = - 0.123, P < 0.001), higher refraction (SRC = - 0.090, P < 0.001). CONCLUSION: IOP fluctuated in children, and a trend toward a higher mean IOP between the ages of 9 and 11 years, which stabilized after 14 years, was observed. IOP was associated with CCT, anterior chamber depth, axial length, lens thickness, mean corneal curvature, spherical equivalent, and systolic blood pressure.
Authors: Bolajoko A Adewara; Bernice O Adegbehingbe; Oluwatoyin H Onakpoya; Chidi G Ihemedu Journal: Int Ophthalmol Date: 2017-03-13 Impact factor: 2.031