Jing Huang1,2, Chaojie Xiong2, Ye Sheng2, Xinhua Zhou2, Cai-De Lu2, Xiujun Cai1. 1. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2. Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China.
Abstract
BACKGROUND: Laparoscopic distal pancreatosplenectomy is an effective and safe surgical modality for treating benign and borderline distal pancreatic tumors, but rarely for pancreatic cancer. This study aimed to compare the feasibility and safety of laparoscopic and open radical antegrade modular pancreatosplenectomy for pancreatic cancer. METHODS: Fifty-one patients with pancreatic cancer who underwent radical antegrade modular pancreatosplenectomy at Ningbo Medical Center Lihuili Hospital between January 2014 and July 2018 were enrolled. 20 patients underwent laparoscopic radical antegrade modular pancreatosplenectomy and 31 patients received open radical antegrade modular pancreatosplenectomy. Postoperative and short-term outcomes of the two groups of patients were analyzed. RESULTS: The mean operation time, length of postoperative hospital stay, and overall postoperative morbidity were similar in the two groups (P>0.05). The laparoscopic radical antegrade modular pancreatosplenectomy group lost less blood (252.5±198.3 vs. 472.6±428.0 mL, P=0.037) and had lower transfusion rates (10.0% vs. 35.4%, P=0.041) than the open radical antegrade modular pancreatosplenectomy group. The laparoscopic group also had statistically significantly earlier passing of first flatus (2.5±0.8 vs. 3.2±1.2 days, P=0.028) and first oral intake (2.9±1.0 vs. 3.7±1.6 days, P=0.042). Furthermore, the rates of postoperative pancreatic fistula (45.0% vs. 32.3%) and overall complications (70.0% vs. 74.2%) were not statistically difference between the two groups. The survival rates at 6 months, 1 year, and 2 years after surgery were not statistically difference between the laparoscopic and open groups (94.4% vs. 93.5, 67.0% vs. 78.0%, and 50.2% vs. 38.3%, respectively). CONCLUSIONS: The results of this study show that laparoscopic radical antegrade modular pancreatosplenectomy is feasible and safe for the treatment of pancreatic cancer. 2021 Gland Surgery. All rights reserved.
BACKGROUND: Laparoscopic distal pancreatosplenectomy is an effective and safe surgical modality for treating benign and borderline distal pancreatic tumors, but rarely for pancreatic cancer. This study aimed to compare the feasibility and safety of laparoscopic and open radical antegrade modular pancreatosplenectomy for pancreatic cancer. METHODS: Fifty-one patients with pancreatic cancer who underwent radical antegrade modular pancreatosplenectomy at Ningbo Medical Center Lihuili Hospital between January 2014 and July 2018 were enrolled. 20 patients underwent laparoscopic radical antegrade modular pancreatosplenectomy and 31 patients received open radical antegrade modular pancreatosplenectomy. Postoperative and short-term outcomes of the two groups of patients were analyzed. RESULTS: The mean operation time, length of postoperative hospital stay, and overall postoperative morbidity were similar in the two groups (P>0.05). The laparoscopic radical antegrade modular pancreatosplenectomy group lost less blood (252.5±198.3 vs. 472.6±428.0 mL, P=0.037) and had lower transfusion rates (10.0% vs. 35.4%, P=0.041) than the open radical antegrade modular pancreatosplenectomy group. The laparoscopic group also had statistically significantly earlier passing of first flatus (2.5±0.8 vs. 3.2±1.2 days, P=0.028) and first oral intake (2.9±1.0 vs. 3.7±1.6 days, P=0.042). Furthermore, the rates of postoperative pancreatic fistula (45.0% vs. 32.3%) and overall complications (70.0% vs. 74.2%) were not statistically difference between the two groups. The survival rates at 6 months, 1 year, and 2 years after surgery were not statistically difference between the laparoscopic and open groups (94.4% vs. 93.5, 67.0% vs. 78.0%, and 50.2% vs. 38.3%, respectively). CONCLUSIONS: The results of this study show that laparoscopic radical antegrade modular pancreatosplenectomy is feasible and safe for the treatment of pancreatic cancer. 2021 Gland Surgery. All rights reserved.
Authors: Irina Pavlik Marangos; Trond Buanes; Bård I Røsok; Airazat M Kazaryan; Arne R Rosseland; Krzysztof Grzyb; Olaug Villanger; Øystein Mathisen; Ivar P Gladhaug; Bjørn Edwin Journal: Surgery Date: 2012-01-28 Impact factor: 3.982
Authors: Jean-Yves Mabrut; Laureano Fernandez-Cruz; Juan Santiago Azagra; Claudio Bassi; Georges Delvaux; Joseph Weerts; Jean-Michel Fabre; Jean Boulez; Jacques Baulieux; Jean-Louis Peix; Jean-François Gigot Journal: Surgery Date: 2005-06 Impact factor: 3.982
Authors: S Rehman; S K P John; R Lochan; B C Jaques; D M Manas; R M Charnley; J J French; S A White Journal: World J Surg Date: 2014-02 Impact factor: 3.352
Authors: Claudio Bassi; Giovanni Marchegiani; Christos Dervenis; Micheal Sarr; Mohammad Abu Hilal; Mustapha Adham; Peter Allen; Roland Andersson; Horacio J Asbun; Marc G Besselink; Kevin Conlon; Marco Del Chiaro; Massimo Falconi; Laureano Fernandez-Cruz; Carlos Fernandez-Del Castillo; Abe Fingerhut; Helmut Friess; Dirk J Gouma; Thilo Hackert; Jakob Izbicki; Keith D Lillemoe; John P Neoptolemos; Attila Olah; Richard Schulick; Shailesh V Shrikhande; Tadahiro Takada; Kyoichi Takaori; William Traverso; Charles R Vollmer; Christopher L Wolfgang; Charles J Yeo; Roberto Salvia; Marcus Buchler Journal: Surgery Date: 2016-12-28 Impact factor: 3.982
Authors: John A Stauffer; Armando Rosales-Velderrain; Ross F Goldberg; Steven P Bowers; Horacio J Asbun Journal: HPB (Oxford) Date: 2012-11-05 Impact factor: 3.647
Authors: Deepa Magge; William Gooding; Haroon Choudry; Jennifer Steve; Jennifer Steel; Amer Zureikat; Alyssa Krasinskas; Mustapha Daouadi; Kenneth K W Lee; Steven J Hughes; Herbert J Zeh; A James Moser Journal: JAMA Surg Date: 2013-06 Impact factor: 14.766
Authors: Olga Kantor; Darren S Bryan; Mark S Talamonti; Waseem Lutfi; Susan Sharpe; David J Winchester; Richard A Prinz; Marshall S Baker Journal: J Gastrointest Surg Date: 2017-08-01 Impact factor: 3.452