Effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm.

To investigate the effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm (AAA). A total of 84 AAA patients treated in the General Hospital of Northern Theater Command of Chinese PLA from January 2018 to October 2019 were equally divided into the control group and research group according to different surgical methods. The control group underwent laparotomy and the research group received endoluminal repair. The expression levels of serum T-cell subsets, plasma Notch1 and TACE proteins were compared before and 1 week after surgery between the two groups; the expression levels of plasma Notch1 and TACE proteins in patients with different tumor diameters in the research group were compared; the comparison of the surgical indexes and the incidence of complications was conducted. After treatment, the molecular level of CD3+ and CD4+ in the research group was significantly higher than that in the control group, whereas the molecular level of CD8+, and the expression levels of Notch1 and TACE proteins in the plasma were significantly lower than that in the control group (P < 0.05). In the research group, the expression levels of plasma Notch1 and TACE proteins were in direct proportion with tumor diameter (P < 0.05). The intraoperative blood loss in the research group was significantly less than that in the control group, the operation time, postoperative fasting time and postoperative hospital stay were significantly shorter than that in the control group, and the total incidence of complications (11.90%) was significantly lower than that in the control group (38.09%) (P < 0.05). At 12 months after operation, there was no statistically significant difference in the incidence of complications and mortality between the two groups. Endovascular therapy fro AAA can greatly improve the expression levels of T-lymphocyte subsets, Notch1 and TACE proteins, and markedly reduce the incidence of complications. AJTR