| Literature DB >> 3384113 |
J M Yovich1, W R Edirisinghe, J M Cummins, J L Yovich.
Abstract
In vitro trials with washed spermatozoa incubated in medium containing 1 mg/ml of the methyl xanthine phosphodiesterase inhibitor PF showed improved counts of total motile and total progressively motile spermatozoa in cases of oligospermia/asthenospermia. Application of this agent in a PROST program for a series of nine couples presenting for treatment with histories of failed fertilization in vitro resulted in five pregnancies (four singleton, one triplet) and the subsequent delivery of normal infants. The results warrant further evaluation of this sperm treatment for cases of severe male factor infertility.Entities:
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Year: 1988 PMID: 3384113 DOI: 10.1016/s0015-0282(16)60030-4
Source DB: PubMed Journal: Fertil Steril ISSN: 0015-0282 Impact factor: 7.329