Edward Bloch1,2,3, Blanca Flores-Sánchez1,2, Odysseas Georgiadis1,2, Venki Sundaram4, Zubin Saihan1, Omar A Mahroo1,2, Andrew R Webster1,2, Lyndon da Cruz1,2,3. 1. Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. 2. Institute of Ophthalmology, University College London, London, United Kingdom. 3. Wellcome EPSRC Centre for Interventional and Surgical Sciences, University College London, London, United Kingdom; and. 4. Department of Ophthalmology, Luton and Dunstable University Hospital, Luton, United Kingdom.
Abstract
PURPOSE: Stellate nonhereditary idiopathic foveomacular retinoschisis is a disorder characterized by splitting of the retina at the macula, without a known underlying mechanical or inherited cause. This study investigates demographic, anatomical, and functional characteristics of subjects with stellate nonhereditary idiopathic foveomacular retinoschisis, to explore potential underlying mechanisms. METHODS: In this single-site, retrospective, and cross-sectional, observational study, data were collected from 28 eyes from 24 subjects with stellate nonhereditary idiopathic foveomacular retinoschisis. Descriptive statistics were reported, based on the observed anatomico-functional features. RESULTS: The visual acuity remained stable (median 20/20) in all subjects over a median follow-up of 17 months. All cases demonstrated foveomacular retinoschisis within Henle's fiber layer, at the junction of the outer plexiform and outer nuclear layers. This schisis cavity extended beyond the limits of the macular OCT temporally in all eyes. In most affected eyes, there were documented features of peripheral retinoschisis and broad attachment of the posterior hyaloid at the macula. Functional testing in a cross-sectional subset demonstrated normal retinal sensitivity centrally but an absolute scotoma peripherally. CONCLUSION: Stellate nonhereditary idiopathic foveomacular retinoschisis seems to be associated with peripheral retinoschisis and anomalous or incomplete posterior hyaloid detachment. Despite chronic manifestation, this does not significantly affect central visual function but can manifest with profound loss of peripheral visual function.
PURPOSE: Stellate nonhereditary idiopathic foveomacular retinoschisis is a disorder characterized by splitting of the retina at the macula, without a known underlying mechanical or inherited cause. This study investigates demographic, anatomical, and functional characteristics of subjects with stellate nonhereditary idiopathic foveomacular retinoschisis, to explore potential underlying mechanisms. METHODS: In this single-site, retrospective, and cross-sectional, observational study, data were collected from 28 eyes from 24 subjects with stellate nonhereditary idiopathic foveomacular retinoschisis. Descriptive statistics were reported, based on the observed anatomico-functional features. RESULTS: The visual acuity remained stable (median 20/20) in all subjects over a median follow-up of 17 months. All cases demonstrated foveomacular retinoschisis within Henle's fiber layer, at the junction of the outer plexiform and outer nuclear layers. This schisis cavity extended beyond the limits of the macular OCT temporally in all eyes. In most affected eyes, there were documented features of peripheral retinoschisis and broad attachment of the posterior hyaloid at the macula. Functional testing in a cross-sectional subset demonstrated normal retinal sensitivity centrally but an absolute scotoma peripherally. CONCLUSION: Stellate nonhereditary idiopathic foveomacular retinoschisis seems to be associated with peripheral retinoschisis and anomalous or incomplete posterior hyaloid detachment. Despite chronic manifestation, this does not significantly affect central visual function but can manifest with profound loss of peripheral visual function.
Authors: Andrea Govetto; Jean-Pierre Hubschman; David Sarraf; Marta S Figueroa; Ferdinando Bottoni; Roberto dell'Omo; Christine A Curcio; Patrizio Seidenari; Giulia Delledonne; Robert Gunzenhauser; Mariantonia Ferrara; Adrian Au; Gianni Virgili; Antonio Scialdone; Rodolfo Repetto; Mario R Romano Journal: Br J Ophthalmol Date: 2019-07-20 Impact factor: 4.638
Authors: Andreas Bringmann; Tobias Duncker; Claudia Jochmann; Thomas Barth; Gernot I W Duncker; Peter Wiedemann Journal: Acta Ophthalmol Date: 2019-10-26 Impact factor: 3.761
Authors: Kamron N Khan; Anthony Robson; Omar A R Mahroo; Gavin Arno; Chris F Inglehearn; Monica Armengol; Naushin Waseem; Graham E Holder; Keren J Carss; Lucy F Raymond; Andrew R Webster; Anthony T Moore; Martin McKibbin; Maria M van Genderen; James A Poulter; Michel Michaelides Journal: Eur J Hum Genet Date: 2018-02-01 Impact factor: 4.246