| Literature DB >> 33840043 |
Paola Fernandes Pansini1, Isabella Bittencourt do Valle1,2, Thabata Coeli Dias Damasceno1, Priscila Marinho de Abreu1, Anna Clara Gregório Có1, Rossana Verónica Mendoza López3, Jeferson Lenzi4, Ricardo Mai Rocha4, Evandro Duccini Souza4, Maria Paula Curado5, Hisham Mehanna6, Paul Nankivell6, José Roberto Vasconcelos de Podestá4, Sandra Ventorin von Zeidler7.
Abstract
To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0.001), PLK1 (p = 0.001), and p63 (p < 0.001) in parallel to reduced immunostaining of p40 (p < 0.001) and BCL2 (p = 0.029) was observed among the tissue segments analyzed. Our study revealed that survivin, PLK1, p63, p40 and BCL2 play a role in oral tumorigenesis and represent promising biomarkers able to recognize mesenchymal phenotype induction in the transition from nonmalignant cells to tumor cells. These results reveals critical interaction between survivin, PLK1, p63, p40 promising proteins during invasive carcinoma development.Entities:
Keywords: Biomarkers; Dysplasia; Immunohistochemistry; Oral cancer; Progression; Tumor
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Year: 2021 PMID： 33840043 PMCID： PMC8633043 DOI： 10.1007/s12105-021-01322-8
Source DB: PubMed Journal: Head Neck Pathol ISSN： 1936-055X