Hana-May Eadeh1, Ahmed A Ismail2, Gaafar M Abdel Rasoul3, Olfat M Hendy4, James R Olson5, Kai Wang6, Matthew R Bonner7, Diane S Rohlman8. 1. Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA. Electronic address: hana-may-eadeh@uiowa.edu. 2. Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA; Community, Environmental, and Occupational Medicine Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt. 3. Community, Environmental, and Occupational Medicine Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt. 4. Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom, Egypt. 5. Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY, USA; Department of Epidemiology and Environmental Health, State University of New York at Buffalo, Buffalo, NY, USA. 6. Department of Biostatistics, University of Iowa, Iowa City, IA, USA. 7. Department of Epidemiology and Environmental Health, State University of New York at Buffalo, Buffalo, NY, USA. 8. Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA.
Abstract
BACKGROUND: Chronic low-level exposure to organophosphorus pesticides is associated with adverse health effects, including a decline in neurological functioning and long-term impairment. These negative effects may be more detrimental in children and adolescents due to their critical stage in development. Little work has investigated the effects of chronic exposure to pesticides, specifically chlorpyrifos (CPF) during the adolescent period. OBJECTIVES: To examine effects of CPF exposure over a year-long period within a group of male adolescents in Egypt (N = 242, mean age = 17.36), including both pesticide applicators and non-applicators. METHODS: Associations between average CPF exposure (measured via urinary metabolite levels of 3,5,6-trichloro-2-pyridinol [TCPy]) and neurobehavioral functioning were examined in a 1-year longitudinal study. Given previous literature, higher levels of TCPy were expected to be associated with worse neurobehavioral functioning. RESULTS: Using mixed effects linear regression, average TCPy exposure predicted deficits in more complex neurobehavioral tasks (Benton visual retention, digit span reverse, match to sample, serial digit learning, and alternating tapping) with estimates of effects ranging from -0.049 to 0.031. Age (effects ranging from 0.033 to 0.090) and field station (effects ranging from -1.266 to -0.278) were significantly predictive of neurobehavioral functioning over time. An interaction effect was found for field station and TCPy across several neurobehavioral domains. DISCUSSION: Results show that occupational exposure to pesticides may have particularly deleterious effects on complex neurobehavioral domains. Additionally, differences across field stations and the age at which individuals are exposed may be important factors to investigate in future research.
BACKGROUND: Chronic low-level exposure to organophosphorus pesticides is associated with adverse health effects, including a decline in neurological functioning and long-term impairment. These negative effects may be more detrimental in children and adolescents due to their critical stage in development. Little work has investigated the effects of chronic exposure to pesticides, specifically chlorpyrifos (CPF) during the adolescent period. OBJECTIVES: To examine effects of CPF exposure over a year-long period within a group of male adolescents in Egypt (N = 242, mean age = 17.36), including both pesticide applicators and non-applicators. METHODS: Associations between average CPF exposure (measured via urinary metabolite levels of 3,5,6-trichloro-2-pyridinol [TCPy]) and neurobehavioral functioning were examined in a 1-year longitudinal study. Given previous literature, higher levels of TCPy were expected to be associated with worse neurobehavioral functioning. RESULTS: Using mixed effects linear regression, average TCPy exposure predicted deficits in more complex neurobehavioral tasks (Benton visual retention, digit span reverse, match to sample, serial digit learning, and alternating tapping) with estimates of effects ranging from -0.049 to 0.031. Age (effects ranging from 0.033 to 0.090) and field station (effects ranging from -1.266 to -0.278) were significantly predictive of neurobehavioral functioning over time. An interaction effect was found for field station and TCPy across several neurobehavioral domains. DISCUSSION: Results show that occupational exposure to pesticides may have particularly deleterious effects on complex neurobehavioral domains. Additionally, differences across field stations and the age at which individuals are exposed may be important factors to investigate in future research.
Authors: W Kent Anger; Fayssal M Farahat; Pamela J Lein; Michael R Lasarev; James R Olson; Taghreed M Farahat; Diane S Rohlman Journal: Neurotoxicology Date: 2020-01-30 Impact factor: 4.294
Authors: Diane S Rohlman; Ahmed Ismail; Matthew R Bonner; Gaafar Abdel Rasoul; Olfat Hendy; Lizette Ortega Dickey; Kai Wang; James R Olson Journal: Neurotoxicology Date: 2019-05-08 Impact factor: 4.294
Authors: Catherine L Callahan; Lamya A Hamad; James R Olson; Ahmed A Ismail; Gaafar Abdel-Rasoul; Olfat Hendy; Diane S Rohlman; Matthew R Bonner Journal: Int J Hyg Environ Health Date: 2017-09-18 Impact factor: 5.840
Authors: Gaafar M Abdel Rasoul; Mahmoud E Abou Salem; Atef A Mechael; Olfat M Hendy; Diane S Rohlman; Ahmed A Ismail Journal: Neurotoxicology Date: 2008-07-09 Impact factor: 4.294
Authors: Jose R Suarez-Lopez; Noor Nazeeh; Georgia Kayser; José Suárez-Torres; Harvey Checkoway; Dolores López-Paredes; David R Jacobs; Franklin de la Cruz Journal: Environ Res Date: 2020-06-11 Impact factor: 6.498
Authors: Fayssal M Farahat; Corie A Ellison; Matthew R Bonner; Barbara P McGarrigle; Alice L Crane; Richard A Fenske; Michael R Lasarev; Diane S Rohlman; W Kent Anger; Pamela J Lein; James R Olson Journal: Environ Health Perspect Date: 2011-01-11 Impact factor: 9.031