Literature DB >> 33837697

Roles of microglial membranes in Alzheimer's disease.

Jae-Won Shin1, James C Lee2.   

Abstract

The majority of Alzheimer's disease (AD) risk genes are highly and selectively expressed by microglia in the brain. Several of these genes are related to lipid and cholesterol metabolism, lipid synthesis, lipid transport, endocytosis, exocytosis and phagocytosis. Therefore, studying the roles of cellular membrane biophysics in microglial function should improve our understanding of the AD pathology. In this chapter, we discuss how lipid rafts and membrane-cytoskeleton adhesion impact microglial-mediated oxidative stress and clearance of amyloid-β peptide (Aβ). We also discuss potential roles of lipid membrane-bound extracellular vesicles as carriers of pathological factors to promote inflammation and cytotoxicity.
© 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer; Amyloid-β peptide; Caveolae; Cholesterol; Exosomes; Inflammation; Lipid rafts; Membrane-cytoskeleton adhesion; Oxidative stress; Tau

Mesh：

Substances：

Year:  2020        PMID： 33837697      PMCID： PMC8082413          DOI： 10.1016/bs.ctm.2020.08.007

Source DB:  PubMed          Journal:  Curr Top Membr        ISSN： 1063-5823            Impact factor:   3.049


  84 in total

1.  Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing.

Authors:  Xiaoguang Yang; Wenwen Sheng; Grace Y Sun; James C-M Lee
Journal:  Neurochem Int       Date:  2010-12-22       Impact factor: 3.921

2.  "Lipid raft aging" in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease.

Authors:  Mario Díaz; Noemí Fabelo; Isidre Ferrer; Raquel Marín
Journal:  Neurobiol Aging       Date:  2018-03-10       Impact factor: 4.673

Review 3.  Exosomes and Ectosomes in Intercellular Communication.

Authors:  Jacopo Meldolesi
Journal:  Curr Biol       Date:  2018-04-23       Impact factor: 10.834

4.  Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation.

Authors:  Tom Schilling; Claudia Eder
Journal:  Cell Immunol       Date:  2010-08-17       Impact factor: 4.868

5.  Cytosolic Phospholipase A2 Facilitates Oligomeric Amyloid-β Peptide Association with Microglia via Regulation of Membrane-Cytoskeleton Connectivity.

Authors:  Tao Teng; Li Dong; Devin M Ridgley; Shivesh Ghura; Matthew K Tobin; Grace Y Sun; Mary Jo LaDu; James C Lee
Journal:  Mol Neurobiol       Date:  2018-08-15       Impact factor: 5.590

6.  Aβ42 Protofibrils Interact with and Are Trafficked through Microglial-Derived Microvesicles.

Authors:  Lisa K Gouwens; Mudar S Ismail; Victoria A Rogers; Nathan T Zeller; Evan C Garrad; Fatima S Amtashar; Nyasha J Makoni; David C Osborn; Michael R Nichols
Journal:  ACS Chem Neurosci       Date:  2018-03-22       Impact factor: 4.418

7.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330

8.  Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.

Authors:  Véréna Landel; Kévin Baranger; Isabelle Virard; Béatrice Loriod; Michel Khrestchatisky; Santiago Rivera; Philippe Benech; François Féron
Journal:  Mol Neurodegener       Date:  2014-09-11       Impact factor: 14.195

9.  TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.

Authors:  Yaming Wang; Tyler K Ulland; Jason D Ulrich; Wilbur Song; John A Tzaferis; Justin T Hole; Peng Yuan; Thomas E Mahan; Yang Shi; Susan Gilfillan; Marina Cella; Jaime Grutzendler; Ronald B DeMattos; John R Cirrito; David M Holtzman; Marco Colonna
Journal:  J Exp Med       Date:  2016-04-18       Impact factor: 14.307

Review 10.  Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.

Authors:  Kanchan Bisht; Kaushik Sharma; Marie-Ève Tremblay
Journal:  Neurobiol Stress       Date:  2018-05-19
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.