Literature DB >> 33836929

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens.

Pramod K Jangir1, Lois Ogunlana2, R Craig MacLean2.   

Abstract

Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  antibiotic resistance; antimicrobial peptide resistance; bacterial evolution

Mesh：

Substances：

Year:  2021        PMID： 33836929     DOI： 10.1016/j.tim.2021.03.007

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  4 in total

1.  Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply.

Authors:  Alfonso Santos-Lopez; Melissa J Fritz; Jeffrey B Lombardo; Ansen H P Burr; Victoria A Heinrich; Christopher W Marshall; Vaughn S Cooper
Journal:  Evol Med Public Health       Date:  2022-05-30

2.  Temporin B Forms Hetero-Oligomers with Temporin L, Modifies Its Membrane Activity, and Increases the Cooperativity of Its Antibacterial Pharmacodynamic Profile.

Authors:  Philip M Ferguson; Maria Clarke; Giorgia Manzo; Charlotte K Hind; Melanie Clifford; J Mark Sutton; Christian D Lorenz; David A Phoenix; A James Mason
Journal:  Biochemistry       Date:  2022-05-24       Impact factor: 3.321

3.  Evaluation of the Antimicrobial Activity in Host-Mimicking Media and In Vivo Toxicity of Antimicrobial Polymers as Functional Mimics of AMPs.

Authors:  Ramón Garcia Maset; Alexia Hapeshi; Stephen Hall; Robert M Dalgliesh; Freya Harrison; Sébastien Perrier
Journal:  ACS Appl Mater Interfaces       Date:  2022-07-12       Impact factor: 10.383

4.  Nano-Formulation Endows Quorum Quenching Enzyme-Antibiotic Hybrids with Improved Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa.

Authors:  Kristina Ivanova; Aleksandra Ivanova; Javier Hoyo; Silvia Pérez-Rafael; Tzanko Tzanov
Journal:  Int J Mol Sci       Date:  2022-07-11       Impact factor: 6.208
  4 in total

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