Arthriniumsteroids A-D, four new steroids from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212.

Four new steroids derivatives, namely arthriniumsteroids A - D (1-4), together with two known compounds, were isolated from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212. Their structures were elucidated by spectroscopic analysis and by comparison with those reported in the literature. The absolute configuration of 2 was confirmed by single-crystal X-ray diffraction. In bioassay, all compounds showed weak inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells.